format-version: 1.2
idspace: foaf http://xmlns.com/foaf/0.1/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
remark: Comment from annotations.ttl file.
ontology: https://github.com/ontodev/robot/examples/edit.owl
owl-axioms: Prefix(owl:=<http://www.w3.org/2002/07/owl#>)\nPrefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)\nPrefix(xml:=<http://www.w3.org/XML/1998/namespace>)\nPrefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)\nPrefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)\n\n\nOntology(\nDeclaration(Class(<http://purl.obolibrary.org/obo/UBERON_0001062>))\n############################\n#   Classes\n############################\n\n# Class: <http://purl.obolibrary.org/obo/UBERON_0001062> (<http://purl.obolibrary.org/obo/UBERON_0001062>)\n\nSubClassOf(<http://purl.obolibrary.org/obo/UBERON_0001062> owl:Thing)\n\n\n)

[Term]
id: UBERON:0000061
name: anatomical structure
namespace: uberon
def: "Material anatomical entity that has inherent 3D shape and is generated by coordinated expression of the organism's own genome." [CARO:0000003]
subset: upper_level
synonym: "biological structure" EXACT []
xref: AAO:0010825
xref: AEO:0000003
xref: BILA:0000003
xref: CARO:0000003
xref: EHDAA2:0003003
xref: EMAPA:0
xref: FBbt:00007001
xref: FMA:67135
xref: GAID:781
xref: HAO:0000003
xref: http://dbpedia.org/ontology/AnatomicalStructure
xref: http://www.snomedbrowser.com/Codes/Details/362889002
xref: MA:0003000
xref: MESH:A13
xref: TAO:0000037
xref: TGMA:0001823
xref: VHOG:0001759
xref: WBbt:0000100
xref: XAO:0003000
xref: ZFA:0000037
is_a: UBERON:0000465 ! material anatomical entity

[Term]
id: UBERON:0000062
name: organ
namespace: uberon
def: "Anatomical structure that performs a specific function or group of functions [WP]." [http://en.wikipedia.org/wiki/Organ_(anatomy)]
subset: upper_level
synonym: "anatomical unit" RELATED []
synonym: "body organ" RELATED []
synonym: "element" RELATED [UBERON:cjm]
xref: birnlex:4
xref: EFO:0000634
xref: EMAPA:35949
xref: ENVO:01000162
xref: FMA:67498
xref: http://linkedlifedata.com/resource/umls/id/C0178784
xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Organ
xref: http://www.snomedbrowser.com/Codes/Details/272625005
xref: MA:0003001
xref: OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA
xref: OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA
xref: Organ:(anatomy)
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000467 ! anatomical system
property_value: external_definition "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." xsd:string {source="GO:0048513"}
property_value: external_ontology_notes "CARO does not include a generic 'organ' class, only simple and compound organ" xsd:string

[Term]
id: UBERON:0000064
name: organ part
namespace: uberon
def: "Anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas[FMA]." [FMA:82472]
subset: disjointness_axiom_removed
subset: efo_slim
subset: upper_level
synonym: "cardinal organ part" EXACT []
synonym: "regional part of organ" RELATED [NIF_GrossAnatomy:birnlex_16]
xref: AAO:0011124
xref: birnlex:16
xref: EFO:0000635
xref: FMA:82472
xref: http://www.snomedbrowser.com/Codes/Details/113343008
xref: http://www.snomedbrowser.com/Codes/Details/91717005
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000062 ! organ

[Term]
id: UBERON:0000465
name: material anatomical entity
namespace: uberon
def: "Anatomical entity that has mass." [CARO:MAH]
subset: upper_level
xref: AAO:0010264
xref: AEO:0000006
xref: BILA:0000006
xref: CARO:0000006
xref: EHDAA2:0003006
xref: FBbt:00007016
xref: FMA:67165
xref: HAO:0000006
xref: TAO:0001836
xref: TGMA:0001826
xref: VHOG:0001721
is_a: UBERON:0001062 ! anatomical entity

[Term]
id: UBERON:0000467
name: anatomical system
namespace: uberon
def: "Anatomical group that is has as its parts distinct anatomical structures interconnected by anatomical structures at a lower level of granularity[CARO]. A group of organs that work together to perform a certain task [Wikipedia]." [CARO:0000011, CARO:MAH, http://en.wikipedia.org/wiki/Organ_system]
subset: uberon_slim
subset: upper_level
synonym: "body system" EXACT [NIF_GrossAnatomy:birnlex_14]
synonym: "organ system" EXACT []
synonym: "system" BROAD [GO:0048731]
xref: AAO:0000007
xref: AEO:0000011
xref: BILA:0000011
xref: birnlex:14
xref: BSA:0000049
xref: CALOHA:TS-2088
xref: CARO:0000011
xref: EHDAA2:0003011
xref: EHDAA:392
xref: EMAPA:16103
xref: EV:0100000
xref: FBbt:00004856
xref: FMA:7149
xref: galen:AnatomicalSystem
xref: HAO:0000011
xref: http://linkedlifedata.com/resource/umls/id/C0460002
xref: http://www.snomedbrowser.com/Codes/Details/278195005
xref: MA:0000003
xref: OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ
xref: Organ:System
xref: Organ:system
xref: TAO:0001439
xref: TGMA:0001831
xref: UMLS:C0460002 {source="ncithesaurus:Organ_System"}
xref: VHOG:0001725
xref: WBbt:0005746
xref: WBbt:0005763
xref: XAO:0003002
xref: ZFA:0001439
is_a: UBERON:0000480 ! anatomical group
relationship: part_of UBERON:0000468 ! multicellular organism
property_value: seeAlso EHDAA2:0001330

[Term]
id: UBERON:0000468
name: multicellular organism
namespace: uberon
def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, CARO:MAH, http://en.wikipedia.org/wiki/Multi-cellular_organism]
subset: efo_slim
subset: uberon_slim
subset: upper_level
synonym: "animal" NARROW [BTO:0000042]
synonym: "body" RELATED []
synonym: "Koerper" RELATED [BTO:0001489]
synonym: "multi-cellular organism" EXACT [CARO:0000012]
synonym: "organism" EXACT []
synonym: "whole body" RELATED [BTO:0001489]
synonym: "whole organism" EXACT []
xref: AAO:0010026
xref: AEO:0000191
xref: BILA:0000012
xref: birnlex:18
xref: BSA:0000038
xref: BTO:0000042
xref: CARO:0000012
xref: EFO:0002906
xref: EHDAA2:0003103
xref: EHDAA2:0003191
xref: EHDAA:1
xref: EHDAA:9178
xref: EMAPA:25765
xref: EV:0100016
xref: FBbt:00000001
xref: FMA:256135
xref: galen:Organism
xref: HAO:0000012
xref: http://www.snomedbrowser.com/Codes/Details/243928005
xref: Multi-cellular:organism
xref: TADS:0000001
xref: TAO:0001094
xref: TGMA:0001832
xref: VHOG:0000671
xref: WBbt:0007833
xref: Whole:Organism
xref: XAO:0003004
xref: ZFA:0001094
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: editor_note "TODO - split body and mc organism? body continues after death stage" xsd:string
property_value: has_relational_adjective "organismal" xsd:string

[Term]
id: UBERON:0000475
name: organism subdivision
namespace: uberon
def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, CARO:MAH]
subset: efo_slim
subset: uberon_slim
subset: upper_level
synonym: "anatomic region" EXACT [MA:0002433]
synonym: "body part" RELATED []
synonym: "body region" RELATED [FMA:7153]
synonym: "cardinal body part" RELATED [FMA:7153]
xref: AAO:0010053
xref: AEO:0000032
xref: BILA:0000032
xref: birnlex:7
xref: Body:Part
xref: Body:part
xref: CALOHA:TS-2084
xref: CARO:0000032
xref: EFO:0000808
xref: EHDAA2:0003032
xref: FBbt:00007009
xref: FMA:7153
xref: galen:BodyPart
xref: HAO:0000032
xref: http://linkedlifedata.com/resource/umls/id/C0229962
xref: MA:0002433
xref: MAT:0000293
xref: MESH:A01
xref: MIAA:0000293
xref: OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA
xref: TAO:0001308
xref: TGMA:0001840
xref: UMLS:C0229962 {source="ncithesaurus:Body_Part"}
xref: VHOG:0001758
xref: XAO:0003013
xref: ZFA:0001308
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: editor_note "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" xsd:string

[Term]
id: UBERON:0000480
name: anatomical group
namespace: uberon
def: "Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue." [CARO:0000054, CARO:MAH]
subset: upper_level
xref: AAO:0010008
xref: AEO:0000054
xref: BILA:0000054
xref: CARO:0000054
xref: EHDAA2:0003054
xref: HAO:0000054
xref: TAO:0001512
xref: TGMA:0001846
xref: VHOG:0001724
xref: XAO:0003001
xref: ZFA:0001512
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0000916
name: abdomen
namespace: uberon
def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [UBERON:cjm]
subset: efo_slim
subset: uberon_slim
synonym: "abdominopelvic region" EXACT [FMA:9577]
synonym: "abdominopelvis" EXACT [FMA:9577]
synonym: "adult abdomen" RELATED []
synonym: "belly" RELATED []
synonym: "celiac region" RELATED []
xref: BTO:0000020
xref: CALOHA:TS-0001
xref: EFO:0000968
xref: EMAPA:35102
xref: EV:0100011
xref: FMA:9577
xref: GAID:16
xref: galen:Abdomen
xref: http://en.wikipedia.org/wiki/Abdomen
xref: http://www.snomedbrowser.com/Codes/Details/302553009
xref: MA:0000029
xref: MAT:0000298
xref: MESH:A01.047
xref: MIAA:0000298
xref: OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA
is_a: UBERON:0009569 ! subdivision of trunk
relationship: part_of UBERON:0002417 ! abdominal segment of trunk
property_value: editor_note "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" xsd:string
property_value: has_relational_adjective "abdominal" xsd:string

[Term]
id: UBERON:0000949
name: endocrine system
namespace: uberon
def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [http://en.wikipedia.org/wiki/Endocrine_system, NLM:endocrine+system]
subset: efo_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "endocrine glandular system" EXACT [EHDAA2:0002224]
synonym: "endocrine system" EXACT []
synonym: "systema endocrinum" EXACT []
xref: AAO:0010279
xref: CALOHA:TS-1301
xref: EFO:0002969
xref: EHDAA2:0002224
xref: EMAPA:35306
xref: Endocrine:System
xref: Endocrine:system
xref: EV:0100128
xref: FBbt:00005068
xref: FMA:9668
xref: GAID:439
xref: http://linkedlifedata.com/resource/umls/id/C0014136
xref: http://www.snomedbrowser.com/Codes/Details/278876000
xref: MA:0000012
xref: MESH:A06
xref: TAO:0001158
xref: UMLS:C0014136 {source="ncithesaurus:Endocrine_System"}
xref: VHOG:0000098
xref: XAO:0000158
xref: ZFA:0001158
is_a: UBERON:0000467 ! anatomical system
property_value: external_definition "Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010279", ontology="AAO", source="AAO:BJB"}
property_value: has_relational_adjective "endocrine" xsd:string
property_value: homology_notes "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000098", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009)"}

[Term]
id: UBERON:0001062
name: anatomical entity
namespace: uberon
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH, FMA:62955]
subset: upper_level
xref: AAO:0010841
xref: AEO:0000000
xref: BILA:0000000
xref: birnlex:6
xref: CARO:0000000
xref: EHDAA2:0002229
xref: FBbt:10000000
xref: FBbt_root:00000000
xref: FMA:62955
xref: HAO:0000000
xref: http://linkedlifedata.com/resource/umls/id/C1515976
xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Anatomic_Structure_System_or_Substance
xref: MA:0000001
xref: TAO:0100000
xref: TGMA:0001822
xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"}
xref: XAO:0000000
xref: ZFA:0100000

[Term]
id: UBERON:0001235
name: adrenal cortex
namespace: uberon
def: "Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol respectively. It is also a secondary site of androgen synthesis. [WP,unvetted]." [http://en.wikipedia.org/wiki/Adrenal_cortex]
subset: efo_slim
subset: uberon_slim
synonym: "adrenal gland cortex" EXACT []
synonym: "cortex (glandula suprarenalis)" EXACT []
synonym: "cortex glandulae suprarenalis" RELATED LATIN [http://en.wikipedia.org/wiki/Adrenal_cortex]
synonym: "cortex glandulae suprarenalis" RELATED [BTO:0000045]
synonym: "cortex of adrenal gland" EXACT []
synonym: "cortex of suprarenal gland" EXACT []
synonym: "suprarenal" RELATED []
synonym: "suprarenal cortex" EXACT []
xref: AAO:0011009
xref: Adrenal:Cortex
xref: Adrenal:cortex
xref: BTO:0000045
xref: CALOHA:TS-0015
xref: EFO:0000237
xref: EMAPA:18427
xref: EV:0100136
xref: FMA:15632
xref: GAID:447
xref: http://linkedlifedata.com/resource/umls/id/C0001613
xref: http://www.snomedbrowser.com/Codes/Details/362584002
xref: MA:0000118
xref: MAT:0000494
xref: MESH:A06.407.071.140
xref: UMLS:C0001613 {source="ncithesaurus:Adrenal_Cortex"}
xref: VHOG:0001481
xref: XAO:0000165
is_a: UBERON:0001851 ! cortex
intersection_of: UBERON:0001851 ! cortex
intersection_of: part_of UBERON:0002369 ! adrenal gland
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Gray1185.png/200px-Gray1185.png
property_value: homology_notes "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001481", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9"}
property_value: taxon_notes "Kardong states that mammals are the first to have distinct cortext and medulla, but this contradicts XAO" xsd:string

[Term]
id: UBERON:0001851
name: cortex
namespace: uberon
def: "Outermost layer of an organ[WP]." [http://en.wikipedia.org/wiki/Cortex_(anatomy)]
subset: uberon_slim
subset: upper_level
synonym: "cortex" EXACT [FMA:61109]
synonym: "cortex of organ" EXACT []
xref: Cortex:(anatomy)
xref: EFO:0000383
xref: EHDAA:9344
xref: FMA:61109
xref: galen:Cortex
is_a: UBERON:0000064 ! organ part
relationship: bounding_layer_of UBERON:0000062 ! organ
property_value: external_ontology_notes "this class is used more generically than in FMA, and includes e.g. cortex of hair" xsd:string {external_ontology="FMA"}
property_value: has_relational_adjective "cortical" xsd:string

[Term]
id: UBERON:0002100
name: trunk
namespace: uberon
def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [http://en.wikipedia.org/wiki/Torso, TAO:0001115, UBERONREF:0000006]
subset: efo_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "Rumpf" RELATED [BTO:0001493]
synonym: "thoracolumbar region" EXACT []
synonym: "torso" EXACT []
synonym: "trunk region" EXACT [XAO:0000054]
xref: AAO:0010339
xref: BILA:0000116
xref: BTO:0001493
xref: CALOHA:TS-1071
xref: EFO:0000966
xref: EMAPA:31857
xref: FMA:7181
xref: galen:Trunk
xref: http://en.wikipedia.org/wiki/Torso
xref: http://linkedlifedata.com/resource/umls/id/C0460005
xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Trunk
xref: http://www.snomedbrowser.com/Codes/Details/262225004
xref: MA:0000004
xref: MAT:0000296
xref: MIAA:0000296
xref: OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA
xref: TAO:0001115
xref: UMLS:C0460005 {source="ncithesaurus:Trunk"}
xref: XAO:0000054
xref: XAO:0003025
xref: ZFA:0001115
is_a: UBERON:0011676 ! subdivision of organism along main body axis
relationship: part_of UBERON:0013702 ! body proper
property_value: external_definition "Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010339", ontology="AAO", source="AAO:BJB"}
property_value: external_definition "Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001115", ontology="TAO", source="ZFIN:curator"}

[Term]
id: UBERON:0002368
name: endocrine gland
namespace: uberon
def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [http://en.wikipedia.org/wiki/Endocrine_gland]
subset: organ_slim
subset: uberon_slim
synonym: "ductless gland" EXACT [AEO:0000098]
synonym: "ductless gland" RELATED [http://en.wikipedia.org/wiki/Ductless_gland]
synonym: "glandula endocrina" EXACT []
synonym: "glandulae endocrinae" RELATED LATIN [http://en.wikipedia.org/wiki/Endocrine_gland]
xref: AEO:0000098
xref: BTO:0001488
xref: CALOHA:TS-1300
xref: EHDAA2:0003098
xref: EMAPA:35999
xref: Endocrine:Gland
xref: Endocrine:gland
xref: FMA:9602
xref: GAID:335
xref: http://linkedlifedata.com/resource/umls/id/C0014133
xref: http://www.snomedbrowser.com/Codes/Details/40818001
xref: MA:0002563
xref: MESH:A06.407
xref: OpenCyc:Mx4rvbkiRZwpEbGdrcN5Y29ycA
xref: UMLS:C0014133 {source="ncithesaurus:Endocrine_Gland"}
is_a: UBERON:0002530 ! gland
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: part_of UBERON:0000949 ! endocrine system
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png

[Term]
id: UBERON:0002369
name: adrenal gland
namespace: uberon
def: "Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]." [BTO:0000047, http://en.wikipedia.org/wiki/Adrenal_gland]
subset: organ_slim
subset: uberon_slim
synonym: "adrenal" RELATED [BTO:0000047]
synonym: "adrenal capsule" RELATED [BTO:0000047]
synonym: "adrenal medulla cell" RELATED []
synonym: "atrabiliary capsule" RELATED [BTO:0000047]
synonym: "epinephric gland" RELATED [http://en.wikipedia.org/wiki/Adrenal_gland]
synonym: "epinephros" RELATED [BTO:0000047]
synonym: "glandula adrenalis" EXACT LATIN [http://en.wikipedia.org/wiki/Adrenal_gland]
synonym: "glandula suprarenalis" EXACT LATIN [http://en.wikipedia.org/wiki/Adrenal_gland]
synonym: "glandula suprarenalis" RELATED [BTO:0000047]
synonym: "interrenal gland" RELATED HOMOLOGY [GO:0030325]
synonym: "suprarenal capsule" RELATED [BTO:0000047]
synonym: "suprarenal gland" RELATED [http://en.wikipedia.org/wiki/Adrenal_gland]
xref: AAO:0010551
xref: Adrenal:Gland
xref: Adrenal:gland
xref: BTO:0000047
xref: CALOHA:TS-0016
xref: EFO:0000238
xref: EMAPA:18426
xref: EV:0100135
xref: FMA:9604
xref: GAID:446
xref: galen:AdrenalGland
xref: http://linkedlifedata.com/resource/umls/id/C0001625
xref: http://www.snomedbrowser.com/Codes/Details/181127006
xref: MA:0000116
xref: MAT:0000071
xref: MESH:A06.407.071
xref: MIAA:0000071
xref: OpenCyc:Mx4rvXYiz5wpEbGdrcN5Y29ycA
xref: UMLS:C0001625 {source="ncithesaurus:Adrenal_Gland"}
xref: VHOG:0001141
xref: XAO:0000164
is_a: UBERON:0006858 ! adrenal/interrenal gland
relationship: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000949 ! endocrine system
property_value: external_definition "Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010551", ontology="AAO", source="AAO:BJB"}
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Illu_endocrine_system.jpg/200px-Illu_endocrine_system.jpg
property_value: function_notes "suprarenal cortex manufactures corticosteroids; suprarenal medulla manufactures epinephrine and norepinephrine; suprarenal medulla receives preganglionic sympathetic innervation from the greater thoracic splanchnic n." xsd:string
property_value: homology_notes "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001141", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9"}
property_value: taxon_notes "The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole" xsd:string

[Term]
id: UBERON:0002417
name: abdominal segment of trunk
namespace: uberon
def: "The abdominal segment of the torso." [http://en.wikipedia.org/wiki/Lumbar]
synonym: "abdomen/pelvis/perineum" RELATED [MA:0000021]
synonym: "lower body" RELATED [MA:0000021]
synonym: "lumbar region" RELATED [https://orcid.org/0000-0002-6601-2165]
xref: EMAPA:35104
xref: FMA:259211
xref: http://en.wikipedia.org/wiki/Lumbar
xref: http://www.snomedbrowser.com/Codes/Details/362875007
xref: MA:0000021
is_a: UBERON:0009569 ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis

[Term]
id: UBERON:0002530
name: gland
namespace: uberon
alt_id: UBERON:MIAA_0000021
def: "A gland is an organ in an animal's body that synthesizes a substance for release such as hormones or breast milk, often into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland). A gland is an organ specialised for secretion[GO]." [http://en.wikipedia.org/wiki/Gland]
subset: efo_slim
subset: uberon_slim
synonym: "Druese" RELATED [BTO:0000522]
synonym: "glandula" RELATED [BTO:0000522]
synonym: "glandula" RELATED LATIN [http://en.wikipedia.org/wiki/Gland]
xref: AAO:0000212
xref: AEO:0000096
xref: BTO:0000522
xref: EFO:0000797
xref: EHDAA2:0003096
xref: EHDAA:2161
xref: EHDAA:4475
xref: EHDAA:6522
xref: EMAPA:18425
xref: FBbt:00100317
xref: FMA:86294
xref: galen:Gland
xref: HAO:0000375
xref: http://en.wikipedia.org/wiki/Gland
xref: http://linkedlifedata.com/resource/umls/id/C1285092
xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Gland
xref: http://www.snomedbrowser.com/Codes/Details/134358001
xref: MA:0003038
xref: MAT:0000021
xref: MIAA:0000021
xref: OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA
xref: UMLS:C1285092 {source="ncithesaurus:Gland"}
xref: WikipediaCategory:Glands
is_a: UBERON:0000062 ! organ
property_value: foaf:depicted_by http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png
property_value: has_relational_adjective "glandular" xsd:string

[Term]
id: UBERON:0006858
name: adrenal/interrenal gland
namespace: uberon
def: "This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO]" [GO:0030325]
subset: grouping_class
subset: organ_slim
synonym: "adrenal - interrenal gland" RELATED [VHOG:0001141]
synonym: "adrenal gland - interrenal gland" EXACT [VHOG:0001141]
synonym: "adrenal gland/interrenal tissue" EXACT []
synonym: "suprarenal gland - interrenal gland" RELATED [VHOG:0001141]
xref: VHOG:0001141
is_a: UBERON:0002368 ! endocrine gland
relationship: part_of UBERON:0000916 ! abdomen
property_value: editor_note "keep this grouping class so long as it is required for GO" xsd:string
property_value: homology_notes "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001141", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9"}

[Term]
id: UBERON:0009569
name: subdivision of trunk
namespace: uberon
subset: non_informative
synonym: "region of trunk" EXACT [FMA:25054]
synonym: "trunk subdivision" EXACT [FMA:25054]
xref: FMA:25054
xref: http://www.snomedbrowser.com/Codes/Details/22943007
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0010000
name: multicellular anatomical structure
namespace: uberon
def: "An anatomical structure that has more than one cell as a part." [CARO:0010000]
subset: upper_level
synonym: "multicellular structure" EXACT [FBbt:00100313]
xref: CARO:0010000
xref: FBbt:00100313
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: UBERON:0011676
name: subdivision of organism along main body axis
namespace: uberon
def: "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." [https://orcid.org/0000-0002-6601-2165]
subset: upper_level
synonym: "axial subdivision of organism" EXACT []
synonym: "body segment" RELATED []
synonym: "main body segment" RELATED []
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0013701 ! main body axis
property_value: editor_note "Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem" xsd:string

[Term]
id: UBERON:0013701
name: main body axis
namespace: uberon
def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [https://orcid.org/0000-0002-6601-2165]
is_a: UBERON:0000475 ! organism subdivision

[Term]
id: UBERON:0013702
name: body proper
namespace: uberon
def: "The region of the organism associated with the visceral organs." [AEO:0000103]
subset: non_informative
synonym: "body" RELATED [AEO:0000103]
synonym: "whole body" RELATED [BTO:0001489]
xref: AEO:0000103
xref: BTO:0001489
xref: FMA:231424
is_a: UBERON:0000475 ! organism subdivision
relationship: part_of UBERON:0013701 ! main body axis
property_value: external_definition "Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]." xsd:string {source="FMA:231424"}

[Typedef]
id: bounding_layer_of
name: bounding layer of
namespace: uberon
def: "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" []
comment: A relationship that applies between a continuant and its outer, bounding layer.  Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.
xref: RO:0002007
is_a: part_of ! part_of

[Typedef]
id: curator_notes
name: curator notes
namespace: uberon
xref: IAO:0000232
is_metadata_tag: true

[Typedef]
id: editor_note
name: editor note
namespace: uberon
xref: IAO:0000116
is_metadata_tag: true

[Typedef]
id: external_definition
name: external_definition
namespace: uberon
def: "An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class." [https://orcid.org/0000-0002-6601-2165]
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO
xref: UBPROP:0000001
is_metadata_tag: true

[Typedef]
id: external_ontology_notes
name: external_ontology_notes
namespace: uberon
def: "Notes on how similar or equivalent classes are represented in other ontologies." [https://orcid.org/0000-0002-6601-2165]
xref: UBPROP:0000012
property_value: editor_note "This annotation property may be replaced with an annotation property from an external ontology such as IAO" xsd:string
is_metadata_tag: true

[Typedef]
id: function_notes
name: function_notes
namespace: uberon
def: "Notes on the evolved function of instances of this class." [https://orcid.org/0000-0002-6601-2165]
xref: UBPROP:0000009
property_value: editor_note "This annotation property may be replaced with an annotation property from an external ontology such as IAO" xsd:string
is_metadata_tag: true

[Typedef]
id: has_relational_adjective
name: has_relational_adjective
namespace: uberon
xref: UBPROP:0000007
property_value: curator_notes "Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. " xsd:string
is_metadata_tag: true

[Typedef]
id: homology_notes
name: homology_notes
namespace: uberon
def: "Notes on the homology status of this class." [https://orcid.org/0000-0002-6601-2165]
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO
xref: UBPROP:0000003
is_metadata_tag: true

[Typedef]
id: part_of
name: part_of
namespace: uberon
xref: BFO:0000050
is_transitive: true

[Typedef]
id: taxon_notes
name: taxon_notes
namespace: uberon
def: "Notes on the how instances of this class vary across species." [https://orcid.org/0000-0002-6601-2165]
xref: UBPROP:0000008
is_metadata_tag: true

