<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/ro/ro-base.owl#"
     xml:base="http://purl.obolibrary.org/obo/ro/ro-base.owl"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:obo="http://purl.obolibrary.org/obo/"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:xml="http://www.w3.org/XML/1998/namespace"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:cito="http://purl.org/spar/cito/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:swrl="http://www.w3.org/2003/11/swrl#"
     xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#"
     xmlns:swrlb="http://www.w3.org/2003/11/swrlb#"
     xmlns:terms="http://purl.org/dc/terms/"
     xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
    <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/ro/ro-base.owl">
        <owl:versionIRI rdf:resource="http://purl.obolibrary.org/obo/ro/releases/2021-10-27/ro-base.owl"/>
        <dc:description xml:lang="en">The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies.</dc:description>
        <dc:title xml:lang="en">OBO Relations Ontology</dc:title>
        <terms:license rdf:resource="https://creativecommons.org/publicdomain/zero/1.0/"/>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/bfo-axioms.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 18 Logical Axioms: 7]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/bfo-classes-minimal.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 49 Logical Axioms: 12]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/chemical.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 9 Logical Axioms: 3]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/core.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 311 Logical Axioms: 69]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/el-constraints.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 6 Logical Axioms: 2]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/generated-axioms.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 18 Logical Axioms: 9]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/rohom.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 731 Logical Axioms: 148]</rdfs:comment>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Includes Ontology(OntologyID(OntologyIRI(&lt;http://purl.obolibrary.org/obo/ro/temporal-intervals.owl&gt;) VersionIRI(&lt;null&gt;))) [Axioms: 146 Logical Axioms: 45]</rdfs:comment>
        <foaf:homepage rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI"> https://github.com/oborel/obo-relations/</foaf:homepage>
    </owl:Ontology>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/IAO_0000111 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000111"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000112 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000112"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000114 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000114"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000116 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000116"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000117 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000118 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000119 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000232 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000232"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000424 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000424"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000425 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000425"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000426 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000426">
        <obo:IAO_0000115>An assertion that holds between an OWL Object Property and a string or literal, where the value of the string or literal is a Common Logic sentence of collection of sentences that define the Object Property.</obo:IAO_0000115>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000589 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000589"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000600 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000600"/>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0100001 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0100001"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001900 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001900">
        <obo:IAO_0000115>An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.</obo:IAO_0000115>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002161 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002161">
        <obo:IAO_0000112>tooth SubClassOf &apos;never in taxon&apos; value &apos;Aves&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>x never in taxon T if and only if T is a class, and x does not instantiate the class expression &quot;in taxon some T&quot;. Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/17921072"/>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20973947"/>
        <obo:IAO_0000425>?X DisjointWith RO_0002162 some ?Y </obo:IAO_0000425>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">never in taxon</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/wiki/Taxon-constraints"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002172"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002171 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002171">
        <obo:IAO_0000115>A is mutually_spatially_disjoint_with B if both A and B are classes, and there exists no p such that p is part_of some A and p is part_of some B.</obo:IAO_0000115>
        <obo:IAO_0000118>non-overlapping with</obo:IAO_0000118>
        <obo:IAO_0000118>shares no parts with</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22293552"/>
        <obo:IAO_0000425>Class: &lt;http://www.w3.org/2002/07/owl#Nothing&gt; EquivalentTo: (BFO_0000050 some ?X) and (BFO_0000050 some ?Y)</obo:IAO_0000425>
        <rdfs:label xml:lang="en">mutually spatially disjoint with</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern</rdfs:seeAlso>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002420"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002172 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002172">
        <obo:IAO_0000115>An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">taxonomic class assertion</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/wiki/Taxon-constraints"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002420"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002173 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002173">
        <obo:IAO_0000115>S ambiguous_for_taxon T if the class S does not have a clear referent in taxon T. An example would be the class &apos;manual digit 1&apos;, which encompasses a homology hypotheses that is accepted for some species (e.g. human and mouse), but does not have a clear referent in Aves - the referent is dependent on the hypothesis embraced, and also on the ontogenetic stage.  [PHENOSCPAE:asilomar_mtg]</obo:IAO_0000115>
        <rdfs:label xml:lang="en">ambiguous for taxon</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/wiki/Taxon-constraints"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002172"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002174 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002174">
        <obo:IAO_0000115>S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.</obo:IAO_0000115>
        <obo:IAO_0000117>https://orcid.org/0000-0002-6601-2165</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22293552"/>
        <rdfs:comment>This relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take ongoing coordinated effort to resolve. Example: metencephalon in teleost</rdfs:comment>
        <rdfs:label xml:lang="en">dubious for taxon</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/wiki/Taxon-constraints"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002172"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002175 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002175">
        <obo:IAO_0000115>S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S</obo:IAO_0000115>
        <obo:IAO_0000117>https://orcid.org/0000-0002-6601-2165</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22293552"/>
        <rdfs:label xml:lang="en">present in taxon</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/obophenotype/uberon/wiki/Taxon-constraints"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002172"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002259 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002259">
        <rdfs:label>defined by inverse</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002416 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002416">
        <obo:IAO_0000115>An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">logical macro assertion</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/ro/docs/shortcut-relations/</rdfs:seeAlso>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002419 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002419">
        <obo:IAO_0000115>An assertion that holds between an OWL Annotation Property P and a non-negative integer N, with the interpretation: for any P(i j) it must be the case that | { k : P(i k) } | = N.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">annotation property cardinality</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002423"/>
        <rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#nonNegativeInteger"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002420 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002420">
        <obo:IAO_0000115>A logical macro assertion whose domain is an IRI for a class</obo:IAO_0000115>
        <obo:IAO_0000116>The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL</obo:IAO_0000116>
        <rdfs:label xml:lang="en">logical macro assertion on a class</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002416"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002421 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002421">
        <obo:IAO_0000115>A logical macro assertion whose domain is an IRI for a property</obo:IAO_0000115>
        <rdfs:label xml:lang="en">logical macro assertion on a property</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002416"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002422 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002422">
        <obo:IAO_0000115>Used to annotate object properties to describe a logical meta-property or characteristic of the object property.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">logical macro assertion on an object property</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002421"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002423 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002423">
        <rdfs:label xml:lang="en">logical macro assertion on an annotation property</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002421"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002474 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002474">
        <obo:IAO_0000115>An assertion that holds between an OWL Object Property and a dispositional interpretation that elucidates how OWL Class Axioms or OWL Individuals that use this property are to be interpreted in a dispositional context. For example,  A binds B may be interpreted as A have a mutual disposition that is realized by binding to the other one.</obo:IAO_0000115>
        <rdfs:label>dispositional interpretation</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002475 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002475">
        <obo:IAO_0000112>&apos;pectoral appendage skeleton&apos; has no connections with &apos;pelvic appendage skeleton&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>A is has_no_connections_with B if there are no parts of A or B that have a connection with the other.</obo:IAO_0000115>
        <obo:IAO_0000118>shares no connection with</obo:IAO_0000118>
        <obo:IAO_0000425>Class: &lt;http://www.w3.org/2002/07/owl#Nothing&gt; EquivalentTo: (BFO_0000050 some ?X) and (RO_0002170 some (BFO_0000050 some ?Y))</obo:IAO_0000425>
        <rdfs:label>has no connections with</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002420"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002483 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002483">
        <rdfs:label>inherited annotation property</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002484 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002484">
        <obo:IAO_0000115>Connects an ontology entity (class, property, etc) to a URL from which curator guidance can be obtained. This assertion is inherited in the same manner as functional annotations (e.g. for GO, over SubClassOf and part_of)</obo:IAO_0000115>
        <rdfs:label>curator guidance link</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002483"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002504 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002504">
        <obo:IAO_0000112>brain always_present_in_taxon &apos;Vertebrata&apos;</obo:IAO_0000112>
        <obo:IAO_0000112>forelimb always_present_in_taxon Euarchontoglires</obo:IAO_0000112>
        <obo:IAO_0000115>S always_present_in_taxon T if every fully formed member of taxon T has part some S, or is an instance of S</obo:IAO_0000115>
        <obo:IAO_0000116>This is a very strong relation. Often we will not have enough evidence to know for sure that there are no species within a lineage that lack the structure - loss is common in evolution. However, there are some statements we can make with confidence - no vertebrate lineage could persist without a brain or a heart. All primates are limbed. </obo:IAO_0000116>
        <obo:IAO_0000118>never lost in</obo:IAO_0000118>
        <rdfs:label>always present in taxon</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002175"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002535 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002535">
        <obo:IAO_0000232>This properties were created originally for the annotation of developmental or life cycle stages, such as for example Carnegie Stage 20 in humans. </obo:IAO_0000232>
        <rdfs:label>temporal logical macro assertion on a class</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002420"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002536 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002536">
        <rdfs:label>measurement property has unit</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002423"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002537 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002537">
        <rdfs:label>has start time value</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002535"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002538 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002538">
        <rdfs:label>has end time value</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002535"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002539 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002539">
        <obo:IAO_0000115>Count of number of days intervening between the start of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 0 for this property.</obo:IAO_0000115>
        <rdfs:label>start, days post fertilization</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002537"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002540 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002540">
        <obo:IAO_0000115>Count of number of days intervening between the end of the stage and the time of fertilization according to a reference model. Note that the first day of development has the value of 1 for this property.</obo:IAO_0000115>
        <rdfs:label>end, days post fertilization</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002538"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002541 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002541">
        <obo:IAO_0000115>Count of number of years intervening between the start of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 0 for this property, and the period during which the child is one year old has the value 1.</obo:IAO_0000115>
        <rdfs:label>start, years post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002537"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002542 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002542">
        <obo:IAO_0000115>Count of number of years intervening between the end of the stage and the time of birth according to a reference model. Note that the first year of post-birth development has the value of 1 for this property, and the period during which the child is one year old has the value 2</obo:IAO_0000115>
        <rdfs:label>end, years post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002538"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002543 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002543">
        <obo:IAO_0000115>Count of number of months intervening between the start of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 0 for this property, and the period during which the child is one month old has the value 1.</obo:IAO_0000115>
        <rdfs:label>start, months post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002537"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002544 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002544">
        <obo:IAO_0000115>Count of number of months intervening between the end of the stage and the time of birth according to a reference model. Note that the first month of post-birth development has the value of 1 for this property, and the period during which the child is one month old has the value 2</obo:IAO_0000115>
        <rdfs:label>end, months post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002538"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002545 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002545">
        <obo:IAO_0000115>Defines the start and end of a stage with a duration of 1 month, relative to either the time of fertilization or last menstrual period of the mother (to be clarified), counting from one, in terms of a reference model. Thus if month_of_gestation=3, then the stage is 2 month in.</obo:IAO_0000115>
        <rdfs:label>month of gestation</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002535"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002546 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002546">
        <obo:IAO_0000115>A relationship between a stage class and an anatomical structure or developmental process class, in which the stage is characterized by the appearance of the structure or the occurrence of the biological process</obo:IAO_0000115>
        <rdfs:label>has developmental stage marker</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002535"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002547 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002547">
        <obo:IAO_0000115>Count of number of days intervening between the start of the stage and the time of coitum.</obo:IAO_0000115>
        <obo:IAO_0000232>For mouse staging: assuming that it takes place around midnight during a 7pm to 5am dark cycle (noon of the day on which the vaginal plug is found, the embryos are aged 0.5 days post coitum)</obo:IAO_0000232>
        <rdfs:label>start, days post coitum</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002537"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002548 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002548">
        <obo:IAO_0000115>Count of number of days intervening between the end of the stage and the time of coitum.</obo:IAO_0000115>
        <rdfs:label>end, days post coitum</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002538"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002549 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002549">
        <rdfs:label>start, weeks post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002537"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002550 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002550">
        <rdfs:label>end, weeks post birth</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/temporal-durations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002538"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002560 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002560">
        <obo:IAO_0000115>If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) &lt;-&gt; exists p : Pr(p), x subject-partner-in p, y object-partner-in p</obo:IAO_0000115>
        <rdfs:label>is asymmetric relational form of process class</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/ro/docs/interaction-relations/</rdfs:seeAlso>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002562"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002561 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002561">
        <obo:IAO_0000115>If Rel is the relational form of a process Pr, then it follow that: Rel(x,y) &lt;-&gt; exists p : Pr(p), x partner-in p, y partner-in p</obo:IAO_0000115>
        <rdfs:label>is symmetric relational form of process class</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/ro/docs/interaction-relations/</rdfs:seeAlso>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002562"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002562 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002562">
        <obo:IAO_0000115>R is the relational form of a process if and only if either (1) R is the symmetric relational form of a process or (2) R is the asymmetric relational form of a process</obo:IAO_0000115>
        <rdfs:label>is relational form of process class</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/ro/docs/interaction-relations/</rdfs:seeAlso>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002594"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002575 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002575">
        <obo:IAO_0000115>relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -&gt; exists z1, z2, ..., zn such that x p z1 ... z2n y</obo:IAO_0000115>
        <obo:IAO_0000116>The general property hierarchy is:

  &quot;directly P&quot; SubPropertyOf &quot;P&quot;
  Transitive(P)

Where we have an annotation assertion

  &quot;directly P&quot; &quot;is direct form of&quot; &quot;P&quot;</obo:IAO_0000116>
        <obo:RO_0002423>If we have the annotation P is-direct-form-of Q, and we have inverses P&apos; and Q&apos;, then it follows that P&apos; is-direct-form-of Q&apos;</obo:RO_0002423>
        <terms:creator>Chris Mungall</terms:creator>
        <rdfs:label>is direct form of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/direct-and-indirect-relations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002579 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002579">
        <obo:IAO_0000115>relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p&apos; such that p&apos; is the direct form of q, p&apos; o p&apos; -&gt; p, and forall x,y : x q y -&gt; either (1) x p y or (2) x p&apos; y</obo:IAO_0000115>
        <terms:creator>Chris Mungall</terms:creator>
        <rdfs:label>is indirect form of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/direct-and-indirect-relations/"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002580 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002580">
        <rdfs:label>logical macro assertion on an axiom</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002416"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002581 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002581">
        <obo:IAO_0000115>If R &lt;- P o Q is a defining property chain axiom, then it also holds that R -&gt; P o Q. Note that this cannot be expressed directly in OWL</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002580"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002582 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002582">
        <obo:IAO_0000115>If R &lt;- P o Q is a defining property chain axiom, then (1) R -&gt; P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.</obo:IAO_0000115>
        <rdfs:label>is a defining property chain axiom where second argument is reflexive</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002581"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002594 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002594">
        <obo:IAO_0000115>An annotation property that connects an object property to a class, where the object property is derived from or a shortcut property for the class. The exact semantics of this annotation may vary on a case by case basis.</obo:IAO_0000115>
        <rdfs:label>is relational form of a class</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002601 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002601">
        <obo:IAO_0000115>A shortcut relationship that holds between two entities based on their identity criteria</obo:IAO_0000115>
        <rdfs:label>logical macro assertion involving identity</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002416"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002602 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002602">
        <obo:IAO_0000115>A shortcut relationship between two entities x and y1, such that the intent is that the relationship is functional and inverse function, but there is no guarantee that this property holds.</obo:IAO_0000115>
        <rdfs:label>in approximate one to one relationship with</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002601"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002603 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002603">
        <obo:IAO_0000115>x is approximately equivalent to y if it is the case that x is equivalent, identical or near-equivalent to y</obo:IAO_0000115>
        <obo:IAO_0000232>The precise meaning of this property is dependent upon some contexts. It is intended to group multiple possible formalisms. Possibilities include a probabilistic interpretation, for example, Pr(x=y) &gt; 0.95. Other possibilities include reified statements of belief, for example, &quot;Database D states that x=y&quot;</obo:IAO_0000232>
        <rdfs:label>is approximately equivalent to</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002602"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002604 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002604">
        <obo:IAO_0000112>&apos;anterior end of organism&apos; is-opposite-of &apos;posterior end of organism&apos;</obo:IAO_0000112>
        <obo:IAO_0000112>&apos;increase in temperature&apos; is-opposite-of &apos;decrease in temperature&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) &lt;= M(x,y) or M(y,z) &lt;= M(y,x).</obo:IAO_0000115>
        <rdfs:label>is opposite of</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002602"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002605 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002605">
        <obo:IAO_0000115>x is indistinguishable from y if there exists some distance metric M, and there exists no z such as M(x,z) &lt;= M(x,y) or M(y,z) &lt;= M(y,x).</obo:IAO_0000115>
        <rdfs:label>is indistinguishable from</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002603"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002611 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002611">
        <rdfs:label>evidential logical macro assertion on an axiom</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002580"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002612 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002612">
        <obo:IAO_0000115>A relationship between a sentence and an instance of a piece of evidence in which the evidence supports the axiom</obo:IAO_0000115>
        <obo:IAO_0000232>This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual.</obo:IAO_0000232>
        <rdfs:label>axiom has evidence</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002611"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002613 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002613">
        <obo:IAO_0000115>A relationship between a sentence and an instance of a piece of evidence in which the evidence contradicts the axiom</obo:IAO_0000115>
        <obo:IAO_0000232>This annotation property is intended to be used in an OWL Axiom Annotation to connect an OWL Axiom to an instance of an ECO (evidence type ontology class). Because in OWL, all axiom annotations must use an Annotation Property, the value of the annotation cannot be an OWL individual, the convention is to use an IRI of the individual.</obo:IAO_0000232>
        <rdfs:label>axiom contradicted by evidence</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002611"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002617 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002617">
        <obo:IAO_0000112>In the context of a particular project, the IRI with CURIE NCBIGene:64327 (which in this example denotes a class) is considered to be representative. This means that if we have equivalent classes with IRIs OMIM:605522, ENSEMBL:ENSG00000105983, HGNC:13243 forming an equivalence set, the NCBIGene is considered the representative member IRI. Depending on the policies of the project, the classes may be merged, or the NCBIGene IRI may be chosen as the default in a user interface context.</obo:IAO_0000112>
        <obo:IAO_0000115>this property relates an IRI to the xsd boolean value &quot;True&quot; if the IRI is intended to be the representative IRI for a collection of classes that are mutually equivalent.</obo:IAO_0000115>
        <obo:IAO_0000232>If it is necessary to make the context explicit, an axiom annotation can be added to the annotation assertion</obo:IAO_0000232>
        <rdfs:label>is representative IRI for equivalence set</rdfs:label>
        <rdfs:seeAlso>OWLAPI Reasoner documentation for representativeElement, which follows a similar idea, but selects an arbitrary member</rdfs:seeAlso>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002601"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004048 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004048">
        <obo:IAO_0000115>Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be &quot;+&quot;, &quot;-&quot; or &quot;0&quot;</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:59:29Z</oboInOwl:creation_date>
        <rdfs:label>is directional form of</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004049 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004049">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-14T00:03:16Z</oboInOwl:creation_date>
        <rdfs:label>is positive form of</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004048"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004050 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004050">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-14T00:03:24Z</oboInOwl:creation_date>
        <rdfs:label>is negative form of</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004048"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0040042 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0040042">
        <obo:IAO_0000112>part-of is homeomorphic for independent continuants.</obo:IAO_0000112>
        <obo:IAO_0000115>R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-10-21T19:46:34Z</oboInOwl:creation_date>
        <rdfs:comment>R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C.</rdfs:comment>
        <rdfs:label>is homeomorphic for</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://github.com/oborel/obo-relations/issues/164"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002422"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/valid_for_go_annotation_extension -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pg</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-22T11:05:29Z</oboInOwl:creation_date>
        <rdfs:label xml:lang="en">valid_for_go_annotation_extension</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/subsets/"/>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/valid_for_go_gp2term -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/valid_for_go_gp2term">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pg</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-22T11:05:18Z</oboInOwl:creation_date>
        <rdfs:label xml:lang="en">valid_for_go_gp2term</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/subsets/"/>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/valid_for_go_ontology -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/valid_for_go_ontology">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pg</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-22T11:04:12Z</oboInOwl:creation_date>
        <rdfs:label xml:lang="en">valid_for_go_ontology</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/subsets/"/>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/valid_for_gocam -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/valid_for_gocam">
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pg</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-22T11:05:45Z</oboInOwl:creation_date>
        <rdfs:label xml:lang="en">valid_for_gocam</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/subsets/"/>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/ro/subsets#ro-eco -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/ro/subsets#ro-eco">
        <rdfs:label>eco subset</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/subsets/"/>
        <rdfs:subPropertyOf rdf:resource="http://www.geneontology.org/formats/oboInOwl#SubsetProperty"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/creator -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/creator"/>
    


    <!-- http://purl.org/dc/elements/1.1/description -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/description"/>
    


    <!-- http://purl.org/dc/elements/1.1/license -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/license"/>
    


    <!-- http://purl.org/dc/elements/1.1/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/source"/>
    


    <!-- http://purl.org/dc/elements/1.1/title -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/title"/>
    


    <!-- http://purl.org/dc/terms/contributor -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/contributor"/>
    


    <!-- http://purl.org/dc/terms/creator -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/creator"/>
    


    <!-- http://purl.org/dc/terms/description -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/description"/>
    


    <!-- http://purl.org/dc/terms/license -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/license"/>
    


    <!-- http://purl.org/dc/terms/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/source"/>
    


    <!-- http://purl.org/dc/terms/title -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/terms/title"/>
    


    <!-- http://purl.org/spar/cito/citesAsAuthority -->

    <owl:AnnotationProperty rdf:about="http://purl.org/spar/cito/citesAsAuthority"/>
    


    <!-- http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled -->

    <owl:AnnotationProperty rdf:about="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#isRuleEnabled"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#SubsetProperty -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#SubsetProperty">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">subset_property</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#created_by -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#created_by"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#creation_date -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#creation_date"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#editor_note -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#editor_note"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_broad_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasDbXref -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">database_cross_reference</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasExactSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_exact_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_narrow_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_obo_format_version</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_related_synonym</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#id -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#inSubset -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset">
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">in_subset</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#shorthand -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#shorthand"/>
    


    <!-- http://www.geneontology.org/formats/oboInOwl#source -->

    <owl:AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#source"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#comment -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#comment"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#label -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#seeAlso -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#seeAlso"/>
    


    <!-- http://www.w3.org/2004/02/skos/core#closeMatch -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#closeMatch"/>
    


    <!-- http://xmlns.com/foaf/0.1/homepage -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/homepage"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000060 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000060">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:comment xml:lang="en">accidentally included in BFO 1.2 proposal
        - should have been BFO_0000062</rdfs:comment>
        <rdfs:label xml:lang="en">obsolete preceded by</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000300 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000300">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">OBSOLETE A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">David Osumi-Sutherland</obo:IAO_0000117>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <cito:citesAsAuthority rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22402613"/>
        <rdfs:comment>Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other).</rdfs:comment>
        <rdfs:label xml:lang="en">obsolete in neural circuit with</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000301 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000301">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">OBSOLETE A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next, in which the direction is from the last to the first.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">David Osumi-Sutherland</obo:IAO_0000117>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <cito:citesAsAuthority rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22402613"/>
        <rdfs:comment>Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other).</rdfs:comment>
        <rdfs:label xml:lang="en">obsolete upstream in neural circuit with</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000302 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000302">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">OBSOLETE A relation that holds between a neuron that is synapsed_by another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_by the next, in which the direction is from the last to the first.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">David Osumi-Sutherland</obo:IAO_0000117>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <cito:citesAsAuthority rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/22402613"/>
        <rdfs:comment>Obsoleted as no longer a useful relationship (all neurons in an organism are in a neural circuit with each other).</rdfs:comment>
        <rdfs:label xml:lang="en">obsolete downstream in neural circuit with</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001020 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001020">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0001022"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000112>penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520)</obo:IAO_0000112>
        <obo:IAO_0000115>A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">is allergic trigger for</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001021 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001021">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0001023"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">is autoimmune trigger for</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000112>penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334)</obo:IAO_0000112>
        <obo:IAO_0000115>A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has allergic trigger</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">has autoimmune trigger</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002010 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002010">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>x &apos;regulates in other organism&apos; y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2).</obo:IAO_0000115>
        <obo:IAO_0000117>David Osumi-Sutherland</obo:IAO_0000117>
        <rdfs:label>regulates in other organism</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002012 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002012">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>A part of relation that applies only between occurents.</obo:IAO_0000115>
        <rdfs:label>occurent part of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:24Z</oboInOwl:creation_date>
        <rdfs:comment>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</rdfs:comment>
        <rdfs:label>directly regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:annotatedProperty rdf:resource="http://www.w3.org/2000/01/rdf-schema#comment"/>
        <owl:annotatedTarget>Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:38Z</oboInOwl:creation_date>
        <rdfs:label>directly negatively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002023"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002024 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002024">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002022"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-09-17T13:52:47Z</oboInOwl:creation_date>
        <rdfs:label>directly positively regulated by</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002024"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.</owl:annotatedTarget>
        <oboInOwl:hasDbXref rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GOC:dos</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002211 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002211">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002578"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115>process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000116>We use &apos;regulates&apos; here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of &apos;causally upstream of or within&apos; (aka influences). Consider relabeling to make things more explicit</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>David Hill</obo:IAO_0000117>
        <obo:IAO_0000117>Tanya Berardini</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000119>GO</obo:IAO_0000119>
        <obo:IAO_0000232>Regulation precludes parthood; the regulatory process may not be within the regulated process.</obo:IAO_0000232>
        <obo:IAO_0000589>regulates (processual)</obo:IAO_0000589>
        <obo:IAO_0000600 rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">false</obo:IAO_0000600>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002212 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002212">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002305"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002335"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">negatively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002213 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002213">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002304"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002336"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">positively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002215 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)</obo:IAO_0000112>
        <obo:IAO_0000112>osteoclast SubClassOf &apos;capable of&apos; some &apos;bone resorption&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. </obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function realized in</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/20123131"/>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21208450"/>
        <obo:IAO_0000232>For compatibility with BFO, this relation has a shortcut definition in which the expression &quot;capable of some P&quot; expands to &quot;bearer_of (some realized_by only P)&quot;.</obo:IAO_0000232>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label xml:lang="en">capable of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002216 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002216">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>c stands in this relationship to p if and only if there exists some p&apos; such that c is capable_of p&apos;, and p&apos; is part_of p.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has function in</obo:IAO_0000118>
        <rdfs:label xml:lang="en">capable of part of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://purl.obolibrary.org/obo/ro/docs/reflexivity/"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002217 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002217">
        <obo:IAO_0000115>OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>agent in</obo:IAO_0000118>
        <obo:IAO_0100001 rdf:resource="http://purl.obolibrary.org/obo/RO_0002608"/>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obsoleted as the inverse property was obsoleted.</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete actively participates in</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002218 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002218">
        <obo:IAO_0000115>OBSOLETE x has participant y if and only if x realizes some active role that inheres in y</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>has agent</obo:IAO_0000118>
        <obo:IAO_0100001 rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete has active participant</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002240 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002240">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002244"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event.</obo:IAO_0000115>
        <obo:IAO_0000119>ExO:0000001</obo:IAO_0000119>
        <rdfs:label>has exposure receptor</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002241 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002241">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002309"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event.</obo:IAO_0000115>
        <obo:IAO_0000119>ExO:0000000</obo:IAO_0000119>
        <rdfs:label>has exposure stressor</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002242 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002242">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002244"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor</obo:IAO_0000115>
        <obo:IAO_0000119>ExO:0000055</obo:IAO_0000119>
        <rdfs:label>has exposure route</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002243 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002243">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002244"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>A broad relationship between an exposure event or process and the course takes from the source to the target.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">http://purl.obolibrary.org/obo/ExO_0000004</obo:IAO_0000119>
        <rdfs:label>has exposure transport path</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002244 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002244">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>Any relationship between an exposure event or process and any other entity.</obo:IAO_0000115>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes.</obo:IAO_0000232>
        <rdfs:label>related via exposure to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002263 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002263">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of p if and only if c enables some f that is involved in p&apos; and p&apos; occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p&apos; are processes.</obo:IAO_0000115>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002264 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002264">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002418"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.</obo:IAO_0000112>
        <obo:IAO_0000115>c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.</obo:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002302 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002302">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002606"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>Inverse of &apos;is substance that treats&apos;</obo:IAO_0000115>
        <terms:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</terms:creator>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label>is treated by substance</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002304 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002304">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004047"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</terms:creator>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, positive effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002305 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002305">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004046"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <terms:creator rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</terms:creator>
        <rdfs:comment>holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y</rdfs:comment>
        <rdfs:label>causally upstream of, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002309 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002309">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002244"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002310"/>
        <obo:IAO_0000115>A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event.</obo:IAO_0000115>
        <terms:contributor>Austin Meier</terms:contributor>
        <terms:contributor>Chris Mungall</terms:contributor>
        <terms:contributor>Marie Angelique Laporte</terms:contributor>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-05T17:35:04Z</oboInOwl:creation_date>
        <rdfs:label>has exposure stimulus</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002326 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002326">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002216"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity.</obo:IAO_0000112>
        <obo:IAO_0000112>Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity.</obo:IAO_0000112>
        <obo:IAO_0000112>eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to &quot;ribosome binding&quot;. And all three are part_of an eIF2 complex</obo:IAO_0000112>
        <obo:IAO_0000116>We would like to say

if and only if
 exists c&apos;, p&apos;
  c part_of c&apos; and c&apos; capable_of p
   and
  c capable_of p&apos; and p&apos; part_of p
then
 c contributes_to p

However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119>http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to</obo:IAO_0000119>
        <obo:IAO_0000232>In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. </obo:IAO_0000232>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label xml:lang="en">contributes to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002327 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002327">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>a particular instances of akt-2 enables some instance of protein kinase activity</obo:IAO_0000112>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>catalyzes</obo:IAO_0000118>
        <obo:IAO_0000118>executes</obo:IAO_0000118>
        <obo:IAO_0000118>has</obo:IAO_0000118>
        <obo:IAO_0000118>is catalyzing</obo:IAO_0000118>
        <obo:IAO_0000118>is executing</obo:IAO_0000118>
        <obo:IAO_0000232>This relation differs from the parent relation &apos;capable of&apos; in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.</obo:IAO_0000232>
        <obo:IAO_0000232>This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.</obo:IAO_0000232>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label xml:lang="en">enables</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002331 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002331">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>c involved_in p if and only if c enables some process p&apos;, and p&apos; is part of p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>actively involved in</obo:IAO_0000118>
        <obo:IAO_0000118>enables part of</obo:IAO_0000118>
        <rdfs:label xml:lang="en">involved in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Involved_in"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002334 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002334">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>inverse of regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000589>regulated by (processual)</obo:IAO_0000589>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002335 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002335">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>inverse of negatively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">negatively regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002336 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002336">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002334"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>inverse of positively regulates</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label xml:lang="en">positively regulated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002401 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002401">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:comment>Likely to be obsoleted. See:
https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete has indirect input</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002402 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002402">
        <obo:IAO_0000112>translation SubClassOf has_direct_output some protein</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. </obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>directly produces</obo:IAO_0000118>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete has direct output</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002403 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002403">
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002411"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002402"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:comment>Likely to be obsoleted. See:
https://docs.google.com/document/d/1QMhs9J-P_q3o_rDh-IX4ZEnz0PnXrzLRVkI3vvz8NEQ/edit</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete has indirect output</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002404 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002404">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>inverse of upstream of</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">causally downstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002405 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002405">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002404"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label xml:lang="en">immediately causally downstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002406 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002406">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002629"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>directly positively regulates</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly activates (process to process)</obo:IAO_0000589>
        <rdfs:label xml:lang="en">directly activates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002407 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002407">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002406"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002406"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002406"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002407"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002407"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002406"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002409"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002409"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>p indirectly activates q if and only if p is upstream of q and there is a chain of directly activates relationships connecting p and q, where the chain is of length greater than one.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>indirectly positively regulates</obo:IAO_0000118>
        <obo:RO_0002579 rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
        <rdfs:label xml:lang="en">indirectly activates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002408 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002408">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002630"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>directly negatively regulates</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly inhibits (process to process)</obo:IAO_0000589>
        <rdfs:label xml:lang="en">directly inhibits</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002409 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002409">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002408"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002408"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002408"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002409"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002409"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002408"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>indirectly negatively regulates</obo:IAO_0000118>
        <obo:RO_0002579 rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
        <rdfs:label xml:lang="en">indirectly inhibits</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002410 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002410">
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>This relation groups causal relations between material entities and causal relations between processes</obo:IAO_0000115>
        <obo:IAO_0000116>This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an &apos;activity flow-centric approach&apos;, with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents.

To define causal relations in an activity-flow type network, we make use of 3 primitives:

 * Temporal: how do the intervals of the two occurrents relate? 
 * Is the causal relation regulatory?
 * Is the influence positive or negative

The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are &apos;direct&apos;, &apos;indirect&apos; or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under &apos;temporally related to&apos;). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified.

For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule.

For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral.

Each of these 3 primitives can be composed to yield a cross-product of different relation types.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label xml:lang="en">causally related to</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002411 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002411">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label xml:lang="en">causally upstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002412 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002412">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdfs:label xml:lang="en">immediately causally upstream of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002413 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002413">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002414"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c</obo:IAO_0000115>
        <obo:IAO_0000116>This is currently called &apos;directly provides input for&apos; to be consistent with our terminology where we use &apos;direct&apos; whenever two occurrents succeed one another directly. We may relabel this simply &apos;provides input for&apos;, as directness is implicit</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly provides input for (process to process)</obo:IAO_0000589>
        <rdfs:label xml:lang="en">directly provides input for</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002414 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002414">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000428"/>
        <obo:IAO_0000115>transitive form of directly_provides_input_for</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>This is a grouping relation that should probably not be used in annotation. Consider instead the child relation &apos;directly provides input for&apos; (which may later be relabeled simply to &apos;provides input for&apos;)</obo:IAO_0000232>
        <obo:IAO_0000589>transitively provides input for (process to process)</obo:IAO_0000589>
        <rdfs:label xml:lang="en">transitively provides input for</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002418 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002418">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002427"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>p &apos;causally upstream or within&apos; q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.</obo:IAO_0000115>
        <obo:IAO_0000116>We would like to make this disjoint with &apos;preceded by&apos;, but this is prohibited in OWL2</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>influences (processual)</obo:IAO_0000118>
        <oboInOwl:hasRelatedSynonym>affects</oboInOwl:hasRelatedSynonym>
        <rdfs:label>causally upstream of or within</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002427 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002427">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002501"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>inverse of causally upstream of or within</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <rdfs:label>causally downstream of or within</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002428 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002428">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002431"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>involved in regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002429 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002429">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; positively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in positive regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002430 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002430">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002331"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c involved in regulation of p if c is involved in some p&apos; and p&apos; negatively regulates some p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002428"/>
        <rdfs:label>involved in negative regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002431 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002431">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p</obo:IAO_0000115>
        <obo:IAO_0000116>OWL does not allow defining object properties via a Union</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000118>involved in or reguates</obo:IAO_0000118>
        <rdfs:label>involved in or involved in regulation of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002448 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002448">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011002"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.

A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <oboInOwl:hasExactSynonym>molecularly controls</oboInOwl:hasExactSynonym>
        <rdfs:label>directly regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002449 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002449">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly inhibits</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly decreases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly negatively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002450 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002450">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002448"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. 
For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>directly activates</obo:IAO_0000118>
        <oboInOwl:hasExactSynonym>molecularly increases activity of</oboInOwl:hasExactSynonym>
        <rdfs:label>directly positively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002500 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002500">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002608"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A relationship between a material entity and a process where the material entity has some causal role that influences the process</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal agent in process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002501 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002501">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115>p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between processes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002506 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002506">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000116>The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label>causal relation between entities</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002507 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002507">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002509"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002559"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002508"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000112>A coral reef environment is determined by a particular coral reef</obo:IAO_0000112>
        <obo:IAO_0000115>s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s.</obo:IAO_0000115>
        <obo:IAO_0000116>The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/24330602"/>
        <obo:IAO_0000589>determined by (system to material entity)</obo:IAO_0000589>
        <terms:creator>Chris Mungall</terms:creator>
        <terms:creator>Pier Buttigieg</terms:creator>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>determined by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002508 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002508">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
        <obo:IAO_0000115>inverse of determined by</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000589>determines (material entity to system)</obo:IAO_0000589>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/RO_0002259"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>determines</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002509 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002509">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/RO_0002577"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>s &apos;determined by part of&apos; w if and only if there exists some f such that (1) s &apos;determined by&apos; f and (2) f part_of w, or f=w.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/ro/subsets#ro-eco"/>
        <rdfs:label>determined by part of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002559 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002559">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influenced by (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influenced by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002566 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002566">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002506"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000115>The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>causally influences (entity-centric)</obo:IAO_0000589>
        <rdfs:label>causally influences</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002578 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002578">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002412"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly regulates (processual)</obo:IAO_0000589>
        <obo:RO_0002575 rdf:resource="http://purl.obolibrary.org/obo/RO_0002211"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002584 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002584">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002595"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>gland SubClassOf &apos;has part structure that is capable of&apos; some &apos;secretion by cell&apos;</obo:IAO_0000112>
        <obo:IAO_0000115>s &apos;has part structure that is capable of&apos; p if and only if there exists some part x such that s &apos;has part&apos; x and x &apos;capable of&apos; p</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>has part structure that is capable of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002595 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002595">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.</obo:IAO_0000115>
        <obo:IAO_0000116>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>causal relation between material entity and a process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002596 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002596">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002500"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002211"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>pyrethroid -&gt; growth</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002597 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002597">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002212"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of negatively regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002598 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002598">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002596"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002213"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000112>renin -&gt; arteriolar smooth muscle contraction</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of positively regulating</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002599 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002599">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002597"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>pazopanib -&gt; pathological angiogenesis</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p.</obo:IAO_0000115>
        <obo:IAO_0000118>treats</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000232>The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber.</obo:IAO_0000232>
        <rdfs:label>capable of inhibiting or preventing pathological process</rdfs:label>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002599"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000118"/>
        <owl:annotatedTarget>treats</owl:annotatedTarget>
        <rdfs:comment>Usage of the term &apos;treats&apos; applies when we believe there to be a an inhibitory relationship</rdfs:comment>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002600 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002600">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002598"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>benzene -&gt; cancer [CHEBI]</obo:IAO_0000112>
        <obo:IAO_0000115>Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p.</obo:IAO_0000115>
        <obo:IAO_0000118>causes disease</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>capable of upregulating or causing pathological process</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002606 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002606">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002599"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d.</obo:IAO_0000115>
        <obo:IAO_0000118>treats</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>is substance that treats</rdfs:label>
        <rdfs:seeAlso rdf:resource="https://code.google.com/p/obo-relations/issues/detail?id=46"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002608 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002608">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>Inverse of &apos;causal agent in process&apos;</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <rdfs:label>process has causal agent</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002609 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002609">
        <obo:IAO_0000115>A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.</obo:IAO_0000115>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.</obo:IAO_0000232>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">obsolete related via dependence to</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002629 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002629">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly positively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly positively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002630 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002630">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.</obo:IAO_0000115>
        <obo:IAO_0000119 rdf:resource="http://purl.obolibrary.org/obo/ro/docs/causal-relations"/>
        <obo:IAO_0000589>directly negatively regulates (process to process)</obo:IAO_0000589>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002578"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_annotation_extension"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_ontology"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_gocam"/>
        <rdfs:label>directly negatively regulates</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002449"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>represses expression of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003003 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003003">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002450"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>increases expression of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003302 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003302">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <obo:IAO_0000112>The genetic variant &apos;NM_007294.3(BRCA1):c.110C&gt;A (p.Thr37Lys)&apos; casues or contributes to the disease  &apos;familial breast-ovarian cancer&apos;.

An environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease &apos;skin cancer&apos;.</obo:IAO_0000112>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition.</obo:IAO_0000115>
        <obo:IAO_0000116>Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! &apos;has phenotype&apos; and RO:0002201 ! &apos;phenotype of&apos;.</obo:IAO_0000116>
        <rdfs:comment>Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to.

Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.</rdfs:comment>
        <rdfs:label xml:lang="en">causes or contributes to condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003303 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003303">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">causes condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003304 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003304">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003302"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">contributes to condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003305 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003305">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003304"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual.</obo:IAO_0000115>
        <obo:IAO_0000118>contributes to expressivity of condition</obo:IAO_0000118>
        <rdfs:label xml:lang="en">contributes to severity of condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003306 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003306">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003304"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population.</obo:IAO_0000115>
        <obo:IAO_0000118>contributes to penetrance of condition</obo:IAO_0000118>
        <rdfs:label xml:lang="en">contributes to frequency of condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003307 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003307">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003305"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition.</obo:IAO_0000115>
        <obo:IAO_0000118>is preventative for condition</obo:IAO_0000118>
        <rdfs:comment>Genetic variations can span any level of granularity from a full genome or genotype to an individual gene  or sequence alteration.  These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology).  The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. 

Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.</rdfs:comment>
        <rdfs:label xml:lang="en">ameliorates condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003309 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003309">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0003305"/>
        <obo:IAO_0000115>A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">exacerbates condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003310 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003310">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <obo:IAO_0000115>A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">condition ameliorated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0003311 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0003311">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <obo:IAO_0000115>A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">condition exacerbated by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004000 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004000">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <rdfs:range>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000015"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000019"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                </owl:unionOf>
            </owl:Class>
        </rdfs:range>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a more specific relations</obo:IAO_0000232>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:38:20Z</oboInOwl:creation_date>
        <rdfs:label>condition has genetic basis in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004001 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004001">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004011"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:45:20Z</oboInOwl:creation_date>
        <rdfs:label>has material basis in gain of function germline mutation in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_410295"/>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_410296"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004012"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:45:37Z</oboInOwl:creation_date>
        <rdfs:label>has material basis in loss of function germline mutation in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004003 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004003">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004013"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:45:54Z</oboInOwl:creation_date>
        <rdfs:label>has material basis in germline mutation in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317343"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004004 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004004">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004014"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:46:07Z</oboInOwl:creation_date>
        <rdfs:label>has material basis in somatic mutation in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317344"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004005 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004005">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004015"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:46:26Z</oboInOwl:creation_date>
        <rdfs:label>has major susceptibility factor</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004006 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004006">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004000"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004016"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:46:57Z</oboInOwl:creation_date>
        <rdfs:label>has partial material basis in germline mutation in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004010 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004010">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004018"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a more specific relations</obo:IAO_0000232>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:53:08Z</oboInOwl:creation_date>
        <rdfs:label>is genetic basis for condition</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004011 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004011">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:55:51Z</oboInOwl:creation_date>
        <rdfs:label>is causal gain of function germline mutation of in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_410296"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004012 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004012">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:56:06Z</oboInOwl:creation_date>
        <rdfs:label>is causal loss of function germline mutation of in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_410295"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004013 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004013">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:56:40Z</oboInOwl:creation_date>
        <rdfs:label>is causal germline mutation in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317343"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004014 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004014">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:57:07Z</oboInOwl:creation_date>
        <rdfs:label>is causal somatic mutation in</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317344"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004015 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004015">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition  and that is necessary but not sufficient to develop the condition[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:57:43Z</oboInOwl:creation_date>
        <rdfs:label>is causal susceptibility factor for</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317345"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004016 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004016">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004010"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115>Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet].</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T02:58:43Z</oboInOwl:creation_date>
        <rdfs:label>is causal germline mutation partially giving rise to</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://www.orpha.net/ORDO/Orphanet_317346"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004017 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004017">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004018"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:20:01Z</oboInOwl:creation_date>
        <rdfs:label>realizable has basis in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004018 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004018">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:20:29Z</oboInOwl:creation_date>
        <rdfs:label>is basis for realizable</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004019 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004019">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004017"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004023"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:26:47Z</oboInOwl:creation_date>
        <rdfs:label>disease has basis in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004020 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004020">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004019"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0000006"/>
        <obo:IAO_0000115>A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function.</obo:IAO_0000115>
        <obo:IAO_0000589>disease has basis in dysfunction of (disease to anatomical structure)</obo:IAO_0000589>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:29:32Z</oboInOwl:creation_date>
        <rdfs:label>disease has basis in dysfunction of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004021 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004021">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004019"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000115>A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process.</obo:IAO_0000115>
        <obo:IAO_0000589>disease has basis in disruption of (disease to process)</obo:IAO_0000589>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:37:52Z</oboInOwl:creation_date>
        <rdfs:label>disease has basis in disruption of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004019"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OGMS_0000031"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/UPHENO_0001001"/>
                </owl:unionOf>
            </owl:Class>
        </rdfs:range>
        <obo:IAO_0000115>A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:46:07Z</oboInOwl:creation_date>
        <rdfs:label>disease has basis in feature</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <obo:IAO_0000232>Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject.</obo:IAO_0000232>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:50:54Z</oboInOwl:creation_date>
        <rdfs:label>causal relationship with disease as subject</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004024 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004024">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004023"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004025"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002215"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>A relationship between a disease and a process where the disease process disrupts the execution of the process.</obo:IAO_0000115>
        <obo:IAO_0000589>disease causes disruption of (disease to process)</obo:IAO_0000589>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:51:09Z</oboInOwl:creation_date>
        <rdfs:label>disease causes disruption of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004025 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004025">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004023"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0000006"/>
        <obo:IAO_0000589>disease causes dysfunction of (disease to anatomical entity)</obo:IAO_0000589>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-11-05T03:58:20Z</oboInOwl:creation_date>
        <rdfs:label>disease causes dysfunction of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004028 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004028">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-26T19:45:49Z</oboInOwl:creation_date>
        <rdfs:label>realized in response to stimulus</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004030 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004030">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004019"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/CARO_0000003"/>
        <obo:IAO_0000115>A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-26T19:58:44Z</oboInOwl:creation_date>
        <rdfs:label>disease arises from structure</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004032 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004032">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004047"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:30Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004033 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004033">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0004046"/>
        </owl:propertyChainAxiom>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:49:51Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004034 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004034">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004032"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002304"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c &apos;acts upstream of, positive effect&apos; p if c is enables f, and f is causally upstream of p, and the direction of f is positive</obo:IAO_0000115>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:14Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, positive effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004035 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004035">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004033"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <owl:propertyChainAxiom rdf:parseType="Collection">
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002327"/>
            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/RO_0002305"/>
        </owl:propertyChainAxiom>
        <obo:IAO_0000115>c &apos;acts upstream of, negative effect&apos; p if c is enables f, and f is causally upstream of p, and the direction of f is negative</obo:IAO_0000115>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-01-26T23:53:22Z</oboInOwl:creation_date>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/valid_for_go_gp2term"/>
        <rdfs:label>acts upstream of, negative effect</rdfs:label>
        <rdfs:seeAlso rdf:resource="http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect"/>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004046 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004046">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0004050 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:05Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, negative effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004047 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004047">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:RO_0004049 rdf:resource="http://purl.obolibrary.org/obo/RO_0002418"/>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-03-13T23:55:19Z</oboInOwl:creation_date>
        <rdfs:label>causally upstream of or within, positive effect</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004096 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004096">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004097"/>
        <rdfs:comment>DEPRECATED This relation is similar to but different in important respects to the characteristic-of relation. See comments on that relation for more information.</rdfs:comment>
        <rdfs:label xml:lang="en">DEPRECATED inheres in</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0004097 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0004097">
        <rdfs:label xml:lang="en">DEPRECATED bearer of</rdfs:label>
        <owl:deprecated rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean">true</owl:deprecated>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0009501 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0009501">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002410"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions.</obo:IAO_0000112>
        <obo:IAO_0000112>An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut)</obo:IAO_0000112>
        <obo:IAO_0000112>Environmental polymorphism in butterflies: These butterflies have a &apos;responsivity to day length trait&apos; that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph.</obo:IAO_0000112>
        <obo:IAO_0000115>r &apos;realized in response to&apos; s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r.</obo:IAO_0000115>
        <terms:contributor>Austin Meier</terms:contributor>
        <terms:contributor>Chris Mungall</terms:contributor>
        <terms:contributor>David Osumi-Sutherland</terms:contributor>
        <terms:contributor>Marie Angelique Laporte</terms:contributor>
        <oboInOwl:hasExactSynonym>triggered by process</oboInOwl:hasExactSynonym>
        <rdfs:label xml:lang="en">realized in response to</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit</rdfs:seeAlso>
    </owl:ObjectProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0009501"/>
        <owl:annotatedProperty rdf:resource="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
        <owl:annotatedTarget>triggered by process</owl:annotatedTarget>
        <oboInOwl:hasDbXref>RO:cjm</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011002 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011002">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011003 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011003">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002566"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that regulates the quantity or abundance or concentration of the entity B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra  Touré</obo:IAO_0000117>
        <rdfs:label>regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011004 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011004">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011002"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label xml:lang="en">indirectly regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011007 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011007">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011023"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.

For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>decreases by repression quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011008 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011008">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011024"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B.

For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>increases by expression quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011009 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011009">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011021"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that directly positively regulates the quantity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>directly positively regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011010 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011010">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011021"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A has an activity that directly negatively regulates the quantity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>directly negatively regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011013 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011013">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011004"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>indirectly activates</obo:IAO_0000118>
        <rdfs:label>indirectly positively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011014 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011014">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011010"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000112>AKT1 destabilizes quantity of FOXO (interaction from Signor database: SIGNOR-252844)</obo:IAO_0000112>
        <obo:IAO_0000115>An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>destabilizes quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011015 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011015">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011009"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000112>AKT1 stabilizes quantity of XIAP (interaction from Signor database: SIGNOR-119488)</obo:IAO_0000112>
        <obo:IAO_0000115>An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>stabilizes quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011016 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011016">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011004"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <obo:IAO_0000118>indirectly inhibits</obo:IAO_0000118>
        <rdfs:label>indirectly negatively regulates activity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011021 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011021">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011003"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>directly regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011022 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011022">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011003"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>indirectly regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011023 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011023">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011022"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>indirectly negatively regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0011024 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0011024">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0011022"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B.</obo:IAO_0000115>
        <obo:IAO_0000117>Vasundra Touré</obo:IAO_0000117>
        <rdfs:label>indirectly positively regulates quantity of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0014001 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0014001">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0004019"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OGMS_0000031"/>
        <obo:IAO_0000115>A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:resource="http://orcid.org/0000-0001-5208-3432"/>
        <rdfs:label>disease has infectious agent</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Data properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0002029 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002029">
        <rdfs:range>
            <rdfs:Datatype>
                <owl:onDatatype rdf:resource="http://www.w3.org/2001/XMLSchema#short"/>
                <owl:withRestrictions rdf:parseType="Collection">
                    <rdf:Description>
                        <xsd:minInclusive rdf:datatype="http://www.w3.org/2001/XMLSchema#short">0</xsd:minInclusive>
                    </rdf:Description>
                    <rdf:Description>
                        <xsd:maxInclusive rdf:datatype="http://www.w3.org/2001/XMLSchema#short">100</xsd:maxInclusive>
                    </rdf:Description>
                </owl:withRestrictions>
            </rdfs:Datatype>
        </rdfs:range>
        <obo:IAO_0000115>Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population.</obo:IAO_0000115>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dos</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-22T16:43:28Z</oboInOwl:creation_date>
        <rdfs:comment>This could be used to record the increased infant morality rate in some population compared to wild-type.  For examples of usage see http://purl.obolibrary.org/obo/FBcv_0000351 and subclasses.</rdfs:comment>
        <rdfs:label xml:lang="en">has increased age-specific mortality rate</rdfs:label>
    </owl:DatatypeProperty>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://purl.obolibrary.org/obo/RO_0002029"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000115"/>
        <owl:annotatedTarget>Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population.</owl:annotatedTarget>
        <oboInOwl:hasDbXref>PMID:24138933</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Wikipedia:Infant_mortality</oboInOwl:hasDbXref>
    </owl:Axiom>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000002">
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115 xml:lang="en">An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000003">
        <obo:IAO_0000115 xml:lang="en">An entity that has temporal parts and that happens, unfolds or develops through time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">occurrent</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000004 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000004">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <obo:IAO_0000115 xml:lang="en">A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">independent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000006 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000006">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000141"/>
        <rdfs:label xml:lang="en">spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000015 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000015">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000115 xml:lang="en">An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000016 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000016">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <rdfs:label xml:lang="en">disposition</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000017 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000017">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000115 xml:lang="en">A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">realizable entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000019 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000019">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:label xml:lang="en">quality</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000020 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000020">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <obo:IAO_0000115 xml:lang="en">A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">specifically dependent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000023 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000023">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000115 xml:lang="en">A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000031 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000031">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000115 xml:lang="en">A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">generically dependent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000034 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000034">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <rdfs:label xml:lang="en">function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000040 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000040">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <owl:disjointWith rdf:resource="http://purl.obolibrary.org/obo/BFO_0000141"/>
        <obo:IAO_0000115 xml:lang="en">An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">material entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000141 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000141">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:label xml:lang="en">immaterial entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000000"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000003"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0000006 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000006"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0000007 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000007"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0001001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0001001"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0001010 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0001010"/>
    


    <!-- http://purl.obolibrary.org/obo/CARO_0010000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CARO_0010000"/>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000"/>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000101 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000101"/>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000540 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000540"/>
    


    <!-- http://purl.obolibrary.org/obo/ENVO_01000254 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/ENVO_01000254"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0003674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003674"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0004842 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0004842"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0004872 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0004872"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0005634 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0005634"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0008150 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150"/>
    


    <!-- http://purl.obolibrary.org/obo/GO_0016301 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0016301"/>
    


    <!-- http://purl.obolibrary.org/obo/OGMS_0000031 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OGMS_0000031"/>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000402 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000402"/>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0001199 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0001199"/>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0002124 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0002124"/>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002310 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002310">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000112>An exposure event in which a human is exposed to particulate matter in the air. Here the exposure stimulus/stress is the particulate matter, the receptor is the airways and lungs of the human,</obo:IAO_0000112>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">An exposure event in which a plant is provided with fertilizer. The exposure receptor is the root system of the plant, the stimulus is the fertilizing chemical, the route is via the soil, possibly mediated by symbotic microbes.</obo:IAO_0000112>
        <obo:IAO_0000115>A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism.</obo:IAO_0000115>
        <obo:IAO_0000116>This class is intended as a grouping for various domain and species-specific exposure classes. The ExO class http://purl.obolibrary.org/obo/ExO_0000002 &apos;exposure event&apos; assumes that all exposures involve stressors, which limits the applicability of this class to &apos;positive&apos; exposures, e.g. exposing a plant to beneficial growing conditions.</obo:IAO_0000116>
        <terms:creator>Chris Mungall</terms:creator>
        <oboInOwl:created_by rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cjm</oboInOwl:created_by>
        <oboInOwl:creation_date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-05T17:55:39Z</oboInOwl:creation_date>
        <rdfs:label>exposure event or process</rdfs:label>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/pull/173</rdfs:seeAlso>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002532 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002532">
        <obo:IAO_0000115>Any entity that is ordered in discrete units along a linear axis.</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <rdfs:label>sequentially ordered entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002533 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002533">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002532"/>
        <obo:IAO_0000115>Any individual unit of a collection of like units arranged in a linear order</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>An individual unit can be a molecular entity such as a base pair, or an abstract entity, such as the abstraction of a base pair.</obo:IAO_0000232>
        <rdfs:label>sequence atomic unit</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002534 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002534">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002532"/>
        <obo:IAO_0000115>Any entity that can be divided into parts such that each part is an atomical unit of a sequence</obo:IAO_0000115>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000232>Sequence bearers can be molecular entities, such as a portion of a DNA molecule, or they can be abstract entities, such as an entity representing all human sonic hedgehog regions of the genome with a particular DNA sequence.</obo:IAO_0000232>
        <rdfs:label>sequence bearer</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002577 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/RO_0002577">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000115>A material entity consisting of multiple components that are causally integrated.</obo:IAO_0000115>
        <obo:IAO_0000116>May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43</obo:IAO_0000116>
        <obo:IAO_0000117>Chris Mungall</obo:IAO_0000117>
        <obo:IAO_0000119>http://www.jbiomedsem.com/content/4/1/43</obo:IAO_0000119>
        <rdfs:label>system</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/UPHENO_0001001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UPHENO_0001001"/>
    


    <!-- http://xmlns.com/foaf/0.1/image -->

    <owl:Class rdf:about="http://xmlns.com/foaf/0.1/image"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotations
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <rdf:Description rdf:about="http://www.w3.org/2000/01/rdf-schema#isDefinedBy">
        <obo:IAO_0000589>is defined by</obo:IAO_0000589>
    </rdf:Description>
    <owl:Axiom>
        <owl:annotatedSource rdf:resource="http://www.w3.org/2000/01/rdf-schema#isDefinedBy"/>
        <owl:annotatedProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000589"/>
        <owl:annotatedTarget>is defined by</owl:annotatedTarget>
        <rdfs:comment>This is an experimental annotation</rdfs:comment>
    </owl:Axiom>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Rules
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <rdf:Description rdf:about="urn:swrl#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl#z">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl:var#y">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl:var#z">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description rdf:about="urn:swrl:var#x">
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Variable"/>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#y"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#y"/>
                                <swrl:argument2 rdf:resource="urn:swrl#z"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002213"/>
                                <swrl:argument1 rdf:resource="urn:swrl#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002212"/>
                        <swrl:argument1 rdf:resource="urn:swrl#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
    <rdf:Description>
        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#Imp"/>
        <swrl:body>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002411"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#y"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                        <rdf:first>
                            <rdf:Description>
                                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                                <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002264"/>
                                <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                                <swrl:argument2 rdf:resource="urn:swrl:var#y"/>
                            </rdf:Description>
                        </rdf:first>
                        <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
                    </rdf:Description>
                </rdf:rest>
            </rdf:Description>
        </swrl:body>
        <swrl:head>
            <rdf:Description>
                <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#AtomList"/>
                <rdf:first>
                    <rdf:Description>
                        <rdf:type rdf:resource="http://www.w3.org/2003/11/swrl#IndividualPropertyAtom"/>
                        <swrl:propertyPredicate rdf:resource="http://purl.obolibrary.org/obo/RO_0002263"/>
                        <swrl:argument1 rdf:resource="urn:swrl:var#x"/>
                        <swrl:argument2 rdf:resource="urn:swrl:var#z"/>
                    </rdf:Description>
                </rdf:first>
                <rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
            </rdf:Description>
        </swrl:head>
    </rdf:Description>
</rdf:RDF>



<!-- Generated by the OWL API (version 4.5.6) https://github.com/owlcs/owlapi -->

