Agent-Skills.md

Agent Skills: ClinVar Querier Skill

ClinVar database query skill for clinical variant interpretation and pathogenicity lookup

bioinformaticsID: a5c-ai/babysitter/clinvar-querier

Repository

a5c-ai/babysitter
a5c-aiLicense: MIT
244

Install this agent skill to your local

pnpm dlx add-skill https://github.com/a5c-ai/babysitter/tree/HEAD/plugins/babysitter/skills/babysit/process/specializations/domains/science/bioinformatics/skills/clinvar-querier

Skill Files

Browse the full folder contents for clinvar-querier.

Download Skill

Loading file tree…

plugins/babysitter/skills/babysit/process/specializations/domains/science/bioinformatics/skills/clinvar-querier/SKILL.md

Skill Metadata

Name
clinvar-querier
Description
ClinVar database query skill for clinical variant interpretation and pathogenicity lookup

ClinVar Querier Skill

Purpose

Enable ClinVar database queries for clinical variant interpretation and pathogenicity lookup.

Capabilities

  • Variant significance lookup
  • Submission history retrieval
  • Condition association queries
  • Evidence level assessment
  • Batch variant queries
  • VCF annotation integration

Usage Guidelines

  • Query variants with standard nomenclature
  • Review submission history for context
  • Consider evidence levels in interpretation
  • Batch query for efficiency
  • Integrate with VCF annotation
  • Document ClinVar version dates

Dependencies

  • ClinVar API
  • VarSome API
  • OMIM

Process Integration

  • Clinical Variant Interpretation (clinical-variant-interpretation)
  • Rare Disease Diagnostic Pipeline (rare-disease-diagnostics)
  • Tumor Molecular Profiling (tumor-molecular-profiling)