MAGeCK CRISPR Analyzer Skill
Purpose
Provide MAGeCK CRISPR screen analysis for gene essentiality scoring.
Capabilities
- Guide read counting
- Normalization and QC
- Gene-level analysis
- Pathway enrichment
- MLE model for complex designs
- Visualization outputs
Usage Guidelines
- Count guides accurately from sequencing data
- Normalize counts appropriately
- Calculate gene-level scores
- Enrich for biological pathways
- Use MLE for complex experimental designs
- Generate informative visualizations
Dependencies
- MAGeCK
- BAGEL
- CRISPResso2
Process Integration
- CRISPR Screen Analysis (crispr-screen-analysis)