Agent-Skills.md

Agent Skills: PharmGKB Annotator Skill

PharmGKB pharmacogenomics annotation skill for drug-gene interaction assessment

bioinformaticsID: a5c-ai/babysitter/pharmgkb-annotator

Repository

a5c-ai/babysitter
a5c-aiLicense: MIT
244

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pnpm dlx add-skill https://github.com/a5c-ai/babysitter/tree/HEAD/plugins/babysitter/skills/babysit/process/specializations/domains/science/bioinformatics/skills/pharmgkb-annotator

Skill Files

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plugins/babysitter/skills/babysit/process/specializations/domains/science/bioinformatics/skills/pharmgkb-annotator/SKILL.md

Skill Metadata

Name
pharmgkb-annotator
Description
PharmGKB pharmacogenomics annotation skill for drug-gene interaction assessment

PharmGKB Annotator Skill

Purpose

Provide PharmGKB pharmacogenomics annotation for drug-gene interaction assessment.

Capabilities

  • Star allele calling (Stargazer)
  • Diplotype determination
  • CPIC guideline integration
  • Drug recommendation generation
  • Clinical annotation lookup
  • Dosing guidance extraction

Usage Guidelines

  • Call star alleles accurately
  • Determine diplotypes from genotypes
  • Apply CPIC guidelines for dosing
  • Generate actionable recommendations
  • Review clinical annotations
  • Document guideline versions

Dependencies

  • PharmGKB API
  • Stargazer
  • PharmCAT

Process Integration

  • Pharmacogenomics Analysis (pharmacogenomics-analysis)
  • Clinical Variant Interpretation (clinical-variant-interpretation)