biopython
Primary Python toolkit for molecular biology. Preferred for Python-based PubMed/NCBI queries (Bio.Entrez), sequence manipulation, file parsing (FASTA, GenBank, FASTQ, PDB), advanced BLAST workflows, structures, phylogenetics. For quick BLAST, use gget. For direct REST API, use pubmed-database.
biorxiv-database
Efficient database search tool for bioRxiv preprint server. Use this skill when searching for life sciences preprints by keywords, authors, date ranges, or categories, retrieving paper metadata, downloading PDFs, or conducting literature reviews.
bioservices
Primary Python tool for 40+ bioinformatics services. Preferred for multi-database workflows: UniProt, KEGG, ChEMBL, PubChem, Reactome, QuickGO. Unified API for queries, ID mapping, pathway analysis. For direct REST control, use individual database skills (uniprot-database, kegg-database).
pubmed-database
Direct REST API access to PubMed. Advanced Boolean/MeSH queries, E-utilities API, batch processing, citation management. For Python workflows, prefer biopython (Bio.Entrez). Use this for direct HTTP/REST work or custom API implementations.
Excel Analysis
Analyze Excel spreadsheets, create pivot tables, generate charts, and perform data analysis. Use when analyzing Excel files, spreadsheets, tabular data, or .xlsx files.
pydicom
Python library for working with DICOM (Digital Imaging and Communications in Medicine) files. Use this skill when reading, writing, or modifying medical imaging data in DICOM format, extracting pixel data from medical images (CT, MRI, X-ray, ultrasound), anonymizing DICOM files, working with DICOM metadata and tags, converting DICOM images to other formats, handling compressed DICOM data, or processing medical imaging datasets. Applies to tasks involving medical image analysis, PACS systems, radiology workflows, and healthcare imaging applications.
execute-plan
Execute structured task plans with status tracking. Use when the user provides a plan file path in the format `plans/{current-date}-{task-name}-{version}.md` or explicitly asks you to execute a plan file.
fantasy-world-building
Use when user mentions fantasy, magic system, or world-building for fantastical settings - provides fantasy genre conventions, magic system design patterns, and world-building frameworks
fastapi-templates
Create production-ready FastAPI projects with async patterns, dependency injection, and comprehensive error handling. Use when building new FastAPI applications or setting up backend API projects.
fetch-unresolved-comments
Fetch unresolved PR review comments using GitHub GraphQL API, filtering out resolved and outdated feedback.
ffuf-web-fuzzing
Expert guidance for ffuf web fuzzing during penetration testing, including authenticated fuzzing with raw requests, auto-calibration, and result analysis
file-organizer
Intelligently organizes your files and folders across your computer by understanding context, finding duplicates, suggesting better structures, and automating cleanup tasks. Reduces cognitive load and keeps your digital workspace tidy without manual effort.
file-todos
This skill should be used when managing the file-based todo tracking system in the todos/ directory. It provides workflows for creating todos, managing status and dependencies, conducting triage, and integrating with slash commands and code review processes.
financial-document-parser
Extract and analyze data from invoices, receipts, bank statements, and financial documents. Categorize expenses, track recurring charges, and generate expense reports. Use when user provides financial PDFs or images.
bitcoin-auth-diagnostics
Diagnose and troubleshoot bitcoin-auth token generation and verification issues. This skill should be used when users encounter authentication failures, signature verification errors, or integration problems with the bitcoin-auth library.
clinvar-database
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
blog-post-writer
Transform brain dumps into polished blog posts in Nick Nisi's voice. Use when the user wants to write a blog post with scattered ideas, talking points, and conclusions that need organization into a cohesive narrative with Nick's conversational, authentic, and thoughtful tone.
brand-guidelines
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.
btc-connect
专业的比特币钱包连接技能，支持btc-connect core、react、vue包在React、Vue、Next.js、Nuxt 3项目中的完整集成，包含UniSat和OKX钱包适配、网络切换功能、SSR环境配置、统一Hook API和v0.5.0最新特性
buck2-rule-basics
Guide users through writing their first Buck2 rule to learn fundamental concepts including rules, actions, targets, configurations, analysis, and select(). Use this skill when users want to learn Buck2 basics hands-on or need help understanding rule writing.
canvas-design
Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.
chroma
Open-source embedding database for AI applications. Store embeddings and metadata, perform vector and full-text search, filter by metadata. Simple 4-function API. Scales from notebooks to production clusters. Use for semantic search, RAG applications, or document retrieval. Best for local development and open-source projects.
chrome-devtools
Browser automation, debugging, and performance analysis using Puppeteer CLI scripts. Use for automating browsers, taking screenshots, analyzing performance, monitoring network traffic, web scraping, form automation, and JavaScript debugging.
cirq
Quantum computing framework for building, simulating, optimizing, and executing quantum circuits. Use this skill when working with quantum algorithms, quantum circuit design, quantum simulation (noiseless or noisy), running on quantum hardware (Google, IonQ, AQT, Pasqal), circuit optimization and compilation, noise modeling and characterization, or quantum experiments and benchmarking (VQE, QAOA, QPE, randomized benchmarking).
claude-code-analyzer
Analyzes Claude Code usage patterns and provides comprehensive recommendations. Runs usage analysis, discovers GitHub community resources, suggests CLAUDE.md improvements, and fetches latest docs on-demand. Use when user wants to optimize their Claude Code workflow, create configurations (agents/skills/commands), or set up project documentation.
find-hypertable-candidates
Analyze an existing PostgreSQL database to identify tables that would benefit from conversion to TimescaleDB hypertables
claude-opus-4-5-migration
Migrate prompts and code from Claude Sonnet 4.0, Sonnet 4.5, or Opus 4.1 to Opus 4.5. Use when the user wants to update their codebase, prompts, or API calls to use Opus 4.5. Handles model string updates and prompt adjustments for known Opus 4.5 behavioral differences. Does NOT migrate Haiku 4.5.
prepare-changelog
Guidelines for preparing changelog entries for nextest releases following Keep a Changelog format
aeon
This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
finishing-a-development-branch
Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured options for merge, PR, or cleanup
flow-nexus-neural
Train and deploy neural networks in distributed E2B sandboxes with Flow Nexus
flow-nexus-platform
Comprehensive Flow Nexus platform management - authentication, sandboxes, app deployment, payments, and challenges
flow-nexus-swarm
Cloud-based AI swarm deployment and event-driven workflow automation with Flow Nexus platform
gitlab-ci-patterns
Build GitLab CI/CD pipelines with multi-stage workflows, caching, and distributed runners for scalable automation. Use when implementing GitLab CI/CD, optimizing pipeline performance, or setting up automated testing and deployment.
gitops-workflow
Implement GitOps workflows with ArgoCD and Flux for automated, declarative Kubernetes deployments with continuous reconciliation. Use when implementing GitOps practices, automating Kubernetes deployments, or setting up declarative infrastructure management.
gpt5-consultant
Use this skill when stuck in circular debugging, when solutions aren't working despite multiple attempts, or when the user expresses frustration with lack of progress. Bring in GPT-5 as a third-party consultant to provide fresh perspective on complex technical problems, architectural decisions, or multi-system debugging issues. Ideal when you've tried multiple approaches without success, when the problem involves obscure edge cases or novel challenges, or when a second expert opinion would help break through an impasse. Gather all context from the conversation so far and present it comprehensively to GPT-5.
grafana-dashboards
Create and manage production Grafana dashboards for real-time visualization of system and application metrics. Use when building monitoring dashboards, visualizing metrics, or creating operational observability interfaces.
helm-chart-scaffolding
Design, organize, and manage Helm charts for templating and packaging Kubernetes applications with reusable configurations. Use when creating Helm charts, packaging Kubernetes applications, or implementing templated deployments.
Hinduism Vedic Wisdom 🕉️
Deploy eternal navigation wisdom - Brahman, Atman, Satchitananda recognition active.
clinpgx-database
Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.
clinicaltrials-database
Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching.
Hook Development
This skill should be used when the user asks to "create a hook", "add a PreToolUse/PostToolUse/Stop hook", "validate tool use", "implement prompt-based hooks", "use ${CLAUDE_PLUGIN_ROOT}", "set up event-driven automation", "block dangerous commands", or mentions hook events (PreToolUse, PostToolUse, Stop, SubagentStop, SessionStart, SessionEnd, UserPromptSubmit, PreCompact, Notification). Provides comprehensive guidance for creating and implementing Claude Code plugin hooks with focus on advanced prompt-based hooks API.
islam-sufism-wisdom
Islamic and Sufi wisdom - Tawhid unity, surrender navigation, 99 Names positions, dhikr practice, fana/baqa dissolution
ispc-lit-tests
Best practices for creating ISPC lit tests. Use when writing regression tests, verifying code generation, or checking compiler diagnostics.
javascript-testing-patterns
Implement comprehensive testing strategies using Jest, Vitest, and Testing Library for unit tests, integration tests, and end-to-end testing with mocking, fixtures, and test-driven development. Use when writing JavaScript/TypeScript tests, setting up test infrastructure, or implementing TDD/BDD workflows.
judaism-hebrew-wisdom
Jewish and Hebrew wisdom - Order before creation, Kabbalah Tree of Life, Gematria navigation, Talmudic argument as collision, Tzimtzum incompleteness
Pair Programming
AI-assisted pair programming with multiple modes (driver/navigator/switch), real-time verification, quality monitoring, and comprehensive testing. Supports TDD, debugging, refactoring, and learning sessions. Features automatic role switching, continuous code review, security scanning, and performance optimization with truth-score verification.
cobrapy
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.
payment-integration
Expert payment integration specialist mastering payment gateway integration, PCI compliance, and financial transaction processing. Specializes in secure payment flows, multi-currency support, and fraud prevention with focus on reliability, compliance, and seamless user experience.
paypal-integration
Integrate PayPal payment processing with support for express checkout, subscriptions, and refund management. Use when implementing PayPal payments, processing online transactions, or building e-commerce checkout flows.
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