bwa-aligner
BWA-MEM2 alignment skill for mapping sequencing reads to reference genomes with optimized parameter selection
cellranger-processor
Cell Ranger skill for 10X Genomics single-cell data processing
clinvar-querier
ClinVar database query skill for clinical variant interpretation and pathogenicity lookup
deepvariant-caller
DeepVariant deep learning variant calling skill for high-accuracy SNV and indel detection
deseq2-differential-expression
DESeq2 differential expression analysis skill with normalization, statistical modeling, and visualization
fastqc-quality-analyzer
Sequencing quality control skill for assessing read quality, adapter contamination, and sequence composition
fusion-gene-detector
Gene fusion detection skill for oncology applications with multiple caller integration
ga4gh-standards-validator
GA4GH standards compliance skill for data sharing and interoperability
gatk-variant-caller
GATK best practices skill for germline and somatic variant calling with joint genotyping
giab-benchmark-validator
Genome in a Bottle benchmark validation skill for pipeline accuracy assessment
gsea-pathway-analyzer
Gene Set Enrichment Analysis skill for functional annotation and pathway interpretation
hipaa-compliance-validator
HIPAA compliance validation skill for genomic data handling and audit
hpo-phenotype-matcher
Human Phenotype Ontology skill for phenotype-driven gene prioritization
humann-functional-profiler
HUMAnN functional profiling skill for metagenomic pathway analysis
igv-genome-browser
IGV integration skill for interactive genome visualization and review
kraken2-taxonomic-classifier
Kraken2 taxonomic classification skill for rapid metagenomic read assignment
process-fmea-generator
Process Failure Mode and Effects Analysis (PFMEA) skill for manufacturing risk assessment
prosthetics-design-optimizer
Prosthetics and orthotics design optimization skill integrating biomechanical requirements with manufacturing constraints
requirements-traceability-manager
Design control traceability skill for managing user needs, design inputs, design outputs, and verification/validation linkages
scaffold-design-optimizer
Tissue engineering scaffold design optimization skill for pore size, porosity, and mechanical properties
software-vv-test-generator
Medical device software verification and validation test case generation skill
sterilization-validation-planner
Sterilization process validation planning skill for EO, radiation, and steam sterilization
udi-labeling-generator
Unique Device Identification (UDI) and labeling compliance skill for generating compliant labels and device identifiers
use-related-risk-analyzer
Use-related risk analysis skill for identifying hazards associated with user interaction per IEC 62366-1
alarm-rationalization-tool
Alarm management skill for alarm rationalization, setpoint optimization, and ISA-18.2 compliance
aspen-plus-simulator
Aspen Plus integration skill for steady-state process simulation, thermodynamic modeling, and equipment rating
catalyst-analyzer
Catalyst performance analysis skill for activity testing, deactivation modeling, and optimization
consequence-modeler
Consequence analysis skill for dispersion modeling, fire/explosion analysis, and effect zone determination
control-strategy-designer
Process control strategy design skill for control structure selection, loop configuration, and regulatory control
corrosion-materials-selector
Materials selection skill for corrosion resistance based on process conditions and industry standards
crystallizer-designer
Crystallization process design skill for nucleation control, crystal size distribution, and equipment selection
distillation-designer
Distillation column design skill for tray/packing selection, hydraulic analysis, and column optimization
energy-auditor
Process energy audit skill for consumption analysis, benchmarking, and efficiency improvement identification
equipment-sizing-calculator
Process equipment sizing skill using established engineering correlations and standards
green-chemistry-metrics
Green chemistry metrics calculation skill for atom economy, E-factor, and process mass intensity
hazop-facilitator
HAZOP study facilitation skill for systematic deviation analysis and safeguard identification
hysys-dynamic-simulator
Aspen HYSYS integration skill for dynamic simulation, pressure-flow networks, and process dynamics
kinetic-modeler
Reaction kinetics modeling skill for parameter estimation, mechanism validation, and rate equation development
lca-analyzer
Life Cycle Assessment skill for environmental impact evaluation and sustainability analysis
material-balance-calculator
Material and energy balance calculation skill for process design and troubleshooting
membrane-system-designer
Membrane separation system design skill for RO, UF, NF, and gas separation applications
mpc-configurator
Model Predictive Control configuration skill for MPC model identification, tuning, and implementation
performance-test-designer
Performance test design skill for test planning, data collection, and acceptance criteria verification
pfd-pid-generator
Process flow diagram and P&ID generation skill with standards compliance and symbol libraries
pid-tuner
PID controller tuning skill for loop optimization using various tuning methods and performance criteria
pinch-analyzer
Heat integration analysis skill using pinch technology for energy targeting and heat exchanger network design
process-economics-estimator
Process economics estimation skill for capital costs, operating costs, and profitability analysis
pssr-checklist-generator
Pre-Startup Safety Review checklist generation skill for startup readiness verification
reactive-hazards-analyzer
Reactive chemical hazards analysis skill for thermal stability, incompatibility, and runaway reaction assessment
reactor-designer
Chemical reactor design skill for sizing, configuration selection, and performance optimization
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