trinity-auto-boot-validator
Generated skill from request: trinity auto-boot validator
1k-sentry
Sentry error tracking and monitoring for OneKey. Use when configuring Sentry, filtering errors, analyzing crash reports, or debugging production issues. Covers platform-specific setup (desktop/mobile/web/extension) and error filtering strategies.
1k-state-management
Jotai state management patterns for OneKey. Use when working with atoms, global state, feature state, or context atoms. Triggers on jotai, atom, state, globalAtom, contextAtom, store, persistence, settings.
1password-cli
Use this skill when working with the 1Password CLI (`op` command) for secrets management, retrieving API keys, injecting secrets into development environments, or any task involving 1Password vault operations. Triggers on: "1password", "op command", "secrets management", "api keys from vault", "op run", "op read", "service account token".
1password-direnv-secrets
Configures 1Password CLI with direnv for fast, secure credential loading. Activates for: 1Password + direnv setup, slow secrets (>2 sec), .env.op files, op:// references, AWS credentials via env vars, --reveal flag issues, repeated biometric prompts, creating 1Password items programmatically, op item get errors. Not for: 1Password GUI usage, SSH keys (use 1Password SSH agent).
1password-secrets
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1password
Set up and use 1Password CLI (op). Use when installing the CLI, enabling desktop app integration, signing in (single or multi-account), or reading/injecting/running secrets via op.
BAM-filtration
Performs data cleaning and removal operations. This skill takes a raw BAM and creates a new, "clean" BAM file by actively removing artifacts: mitochondrial reads, blacklisted regions, PCR duplicates, and unmapped reads. Use this skill to "clean," "filter," or "remove bad reads" from a dataset. This is a prerequisite step before peak calling. Do NOT use this skill if you only want to view statistics without modifying the file.
2-categorize-files
Second step in building instruction context for codebase
design
Create and manage project-specific design systems for SaaS applications. Use when starting a new app (CREATE mode), updating an existing design system (MODIFY mode), or building features that need to follow established patterns (WORK WITHIN mode). Outputs to instructions/design-system.md as the single source of truth for all UX/UI decisions.
identify
Identify friction points, bottlenecks, bugs, and technical debt. Use for audits, debugging sessions, when something feels wrong, or before major work to surface hidden issues. This is the second system in the 5-system framework.
ml-paper-writing
Write publication-ready ML/AI papers for NeurIPS, ICML, ICLR, ACL, AAAI, COLM. Use when drafting papers from research repos, structuring arguments, verifying citations, or preparing camera-ready submissions. Includes LaTeX templates, reviewer guidelines, and citation verification workflows.
differential-tad-analysis
This skill performs differential topologically associating domain (TAD) analysis using HiCExplorer's hicDifferentialTAD tool. It compares Hi-C contact matrices between two conditions based on existing TAD definitions to identify significantly altered chromatin domains.
20-understand-goal-150
[20] UNDERSTAND. Achieve complete clarity on goals, expectations, and success criteria. Use when starting new tasks, when requirements seem unclear, when scope is ambiguous, or anytime you need full understanding of what success looks like. Triggers on \"clarify goal\", \"understand requirements\", \"what exactly needed\", \"define success\", or when facing unclear expectations.
2000s-visualization-expert
Expert in 2000s-era music visualization (Milkdrop, AVS, Geiss) and modern WebGL implementations. Specializes in Butterchurn integration, Web Audio API AnalyserNode FFT data, GLSL shaders for audio-reactive visuals, and psychedelic generative art. Activate on "Milkdrop", "music visualization", "WebGL visualizer", "Butterchurn", "audio reactive", "FFT visualization", "spectrum analyzer". NOT for simple bar charts/waveforms (use basic canvas), video editing, or non-audio visuals.
2026-legal-research-agent
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chaos-spawn-1767390340
🍆👾 CHAOS SPAWN - Maximum jank energy skill generated from pure chaos
differential-methylation
This skill performs differential DNA methylation analysis (DMRs and DMCs) between experimental conditions using WGBS methylation tracks (BED/BedGraph). It standardizes input files into per-sample four-column Metilene tables, constructs a merged methylation matrix, runs Metilene for DMR detection, filters the results, and generates quick visualizations.
21-understand-research-150
[21] UNDERSTAND. Deep research workflow for this project using 150% scope (100% core + 50% boundary), evidence-based reasoning, and structured investigation notes. Use when the task requires investigation, root-cause analysis, or mapping unknown areas. Always maintain a research log file that captures findings, hypotheses, and next branches; use web.run when external verification is needed.
local-methylation-profile
This skill analyzes the local DNA methylation profiles around target genomic regions provide by user. Use this skill when you want to vasulize the average methylation profile around target regions (e.g. TSS, CTCF peak or other target regions).
22-understand-deep-150
[22] UNDERSTAND. Deep research from all sources — internal (code, git, logs) AND external (web, docs, best practices). Use when choosing libraries, investigating solutions, understanding legal/technical questions, comparing approaches, or anytime you need comprehensive knowledge from both project context and world knowledge. Triggers on \"research\", \"investigate\", \"find best approach\", \"what do others do\", \"compare options\", or complex questions requiring multiple sources.
integrative-DMR-DEG
This skill performs correlation analysis between differential methylation and differential gene expression, identifying genes with coordinated epigenetic regulation. It provides preprocessing and integration workflows, using promoter-level methylation–expression relationships.
23-understand-ask-ai-150
[23] UNDERSTAND. Consult external AI models when internal sources are exhausted. Build quality prompts using Prompt150 formula (Context + Query + Method + Style). Use when Loop150 exhausts internal sources, need real-world precedents, confidence <75%, or require reasoning from specialized AI models.
global-methylation-profile
This skill performs genome-wide DNA methylation profiling. It supports single-sample and multi-sample workflows to compute methylation density distributions, genomic feature distribution of the methylation profile, and sample-level clustering/PCA. Use it when you want to systematically characterize global methylation patterns from WGBS or similar per-CpG methylation call files.
methylation-variability-analysis
This skill provides a complete and streamlined workflow for performing methylation variability and epigenetic heterogeneity analysis from whole-genome bisulfite sequencing (WGBS) data. It is designed for researchers who want to quantify CpG-level variability across biological samples or conditions, identify highly variable CpGs (HVCs), and explore epigenetic heterogeneity.
UMR-LMR-PMD-detection
This pipeline performs genome-wide segmentation of CpG methylation profiles to identify Unmethylated Regions (UMRs), Low-Methylated Regions (LMRs), and Partially Methylated Domains (PMDs) using whole-genome bisulfite sequencing (WGBS) methylation calls. The pipeline provides high-resolution enhancer-like LMRs, promoter-associated UMRs, and large-scale PMDs characteristic of reprogramming, aging, or cancer methylomes, enabling integration with chromatin accessibility, TF binding, and genome architecture analyses.
correlation-methylation-epiFeatures
This skill provides a complete pipeline for integrating CpG methylation data with chromatin features such as ATAC-seq signal, H3K27ac, H3K4me3, or other histone marks/TF signals.
notion-meeting-intelligence
Prepares meeting materials by gathering context from Notion, enriching with Claude research, and creating both an internal pre-read and external agenda saved to Notion. Helps you arrive prepared with comprehensive background and structured meeting docs.
atac-footprinting
This skill performs transcription factor (TF) footprint analysis using TOBIAS on ATAC-seq data. It corrects Tn5 sequence bias, quantifies TF occupancy at motif sites, generates footprint scores, and optionally compares differential TF binding across conditions.
regulatory-community-analysis-ChIA-PET
This skill performs protein-mediated regulatory community analysis from ChIA-PET datasets and provide a way for visualizing the communities. Use this skill when you have a annotated peak file (in BED format) from ChIA-PET experiment and you want to identify the protein-mediated regulatory community according to the BED and BEDPE file from ChIA-PET.
obsidian-markdown
Create and edit Obsidian Flavored Markdown with wikilinks, embeds, callouts, properties, and other Obsidian-specific syntax. Use when working with .md files in Obsidian, or when the user mentions wikilinks, callouts, frontmatter, tags, embeds, or Obsidian notes.
2agent
Configures 2-Agent workflow between PM and implementation roles. Use when user mentions 2-Agent setup, PM coordination, Cursor setup, or 2-agent operations. Do NOT load for: solo operation, workflow execution, or handoff processing.
competitive-ads-extractor
Extracts and analyzes competitors' ads from ad libraries (Facebook, LinkedIn, etc.) to understand what messaging, problems, and creative approaches are working. Helps inspire and improve your own ad campaigns.
2d-bin-packing
When the user wants to pack 2D rectangular items into bins, optimize 2D cutting patterns, or minimize material waste in 2D packing. Also use when the user mentions "2D packing," "rectangular packing," "sheet packing," "2D bin packing problem," "guillotine cutting," "two-dimensional packing," or "rectangle packing optimization." For 1D problems, see 1d-cutting-stock. For 3D problems, see 3d-bin-packing.
2d-cutting-stock
When the user wants to cut 2D sheets optimally, minimize waste in rectangular sheet cutting, or solve two-dimensional cutting stock problems. Also use when the user mentions "2D cutting," "sheet cutting optimization," "panel cutting," "glass cutting," "steel plate cutting," "guillotine cutting patterns," "two-stage cutting," or "2D trim loss." For 1D problems, see 1d-cutting-stock. For bin packing, see 2d-bin-packing. For irregular shapes, see nesting-optimization.
2d-games
2D game development principles. Sprites, tilemaps, physics, camera.
slack-gif-creator
Toolkit for creating animated GIFs optimized for Slack, with validators for size constraints and composable animation primitives. This skill applies when users request animated GIFs or emoji animations for Slack from descriptions like "make me a GIF for Slack of X doing Y".
raffle-winner-picker
Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency.
build
Build features with AI coding tools (Claude Code, Lovable, Replit, Cursor). Use when implementing specs, iterating on AI code, or choosing tools. Focuses on tool selection, effective prompting, and iteration workflows for non-technical founders.
3-identifying-architecture
Third step in building instruction context for codebase
peak-calling
Perform peak calling for ChIP-seq or ATAC-seq data using MACS3, with intelligent parameter detection from user feedback. Use it when you want to call peaks for ChIP-seq data or ATAC-seq data.
prioritize
Prioritize tasks and issues to determine what to work on and in what order. Use after identification, when planning work, or when unsure what to do next. This is the third system in the 5-system framework.
30-analyze-impact-150
[30] ANALYZE. Understand how changes impact the system — what's the core, what's affected, what depends on what. Use when planning changes, analyzing systems, debugging issues, or anytime you need to see the full picture of cause and effect. Triggers on \"what's affected\", \"impact analysis\", \"dependencies\", \"scope mapping\", or when you need to understand ripple effects.
40-plan-action-150
[40] PLAN. Create clear action plans with steps, success criteria, and risk awareness. Use before implementing features, making changes, starting projects, or anytime you need a roadmap to success. Triggers on \"plan this\", \"how should we approach\", \"what's the strategy\", \"steps to complete\", or when facing complex multi-step work.
hic-matrix-qc
This skill performs standardized quality control (QC) on Hi-C contact matrices stored in .mcool or .cool format. It computes coverage and cis/trans ratios, distance-dependent contact decay (P(s) curves), coverage uniformity, and replicate correlation at a chosen resolution using cooler and cooltools. Use it to assess whether Hi-C data are of sufficient quality for downstream analyses such as TAD calling, loop detection, and compartment analysis.
302ai-api-integration
ALWAYS use this skill when user needs ANY API functionality (AI models, image generation, video, audio, text processing, etc.). Automatically search 302.AI's 1400+ APIs and generate integration code. Use proactively whenever APIs or AI capabilities are mentioned.
31-analyze-think-150
[31] ANALYZE. Universal deep thinking methodology for any situation requiring quality reasoning. Use when solving problems, debugging, making decisions, analyzing code, planning, reviewing, or anytime you need thorough thinking instead of surface-level responses. Triggers on \"think deeply\", \"analyze thoroughly\", \"reason carefully\", \"deep thinking\", \"understand completely\", or any task requiring careful thought.
nested-TAD-detection
This skill detects hierarchical (nested) TAD structures from Hi-C contact maps (in .cool or mcool format) using OnTAD, starting from multi-resolution .mcool files. It extracts a user-specified chromosome and resolution, converts the data to a dense matrix, runs OnTAD, and organizes TAD calls and logs for downstream 3D genome analysis.
32-analyze-verify-150
[32] ANALYZE. Ensure every critical claim has verifiable evidence with confidence levels. Each fact must have source + confidence percentage. If confidence <85%, enter Loop150 to find more sources. Use for critical decisions, factual claims, legal/compliance work, or any situation where unverified claims are dangerous.
hic-compartment-shift
This skill performs A/B compartment shift analysis between two Hi-C samples.
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