dask
Parallel/distributed computing. Scale pandas/NumPy beyond memory, parallel DataFrames/Arrays, multi-file processing, task graphs, for larger-than-RAM datasets and parallel workflows.
deepchem
Molecular machine learning toolkit. Property prediction (ADMET, toxicity), GNNs (GCN, MPNN), MoleculeNet benchmarks, pretrained models, featurization, for drug discovery ML.
denario
Multiagent AI system for scientific research assistance that automates research workflows from data analysis to publication. This skill should be used when generating research ideas from datasets, developing research methodologies, executing computational experiments, performing literature searches, or generating publication-ready papers in LaTeX format. Supports end-to-end research pipelines with customizable agent orchestration.
diffdock
Diffusion-based molecular docking. Predict protein-ligand binding poses from PDB/SMILES, confidence scores, virtual screening, for structure-based drug design. Not for affinity prediction.
esm
Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.
etetoolkit
Phylogenetic tree toolkit (ETE). Tree manipulation (Newick/NHX), evolutionary event detection, orthology/paralogy, NCBI taxonomy, visualization (PDF/SVG), for phylogenomics.
matchms
Mass spectrometry analysis. Process mzML/MGF/MSP, spectral similarity (cosine, modified cosine), metadata harmonization, compound ID, for metabolomics and MS data processing.
matplotlib
Foundational plotting library. Create line plots, scatter, bar, histograms, heatmaps, 3D, subplots, export PNG/PDF/SVG, for scientific visualization and publication figures.
medchem
Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.
polars
Fast DataFrame library (Apache Arrow). Select, filter, group_by, joins, lazy evaluation, CSV/Parquet I/O, expression API, for high-performance data analysis workflows.
pydeseq2
Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.
pysam
Genomic file toolkit. Read/write SAM/BAM/CRAM alignments, VCF/BCF variants, FASTA/FASTQ sequences, extract regions, calculate coverage, for NGS data processing pipelines.
pytdc
Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.
simpy
Process-based discrete-event simulation framework in Python. Use this skill when building simulations of systems with processes, queues, resources, and time-based events such as manufacturing systems, service operations, network traffic, logistics, or any system where entities interact with shared resources over time.
stable-baselines3
Use this skill for reinforcement learning tasks including training RL agents (PPO, SAC, DQN, TD3, DDPG, A2C, etc.), creating custom Gym environments, implementing callbacks for monitoring and control, using vectorized environments for parallel training, and integrating with deep RL workflows. This skill should be used when users request RL algorithm implementation, agent training, environment design, or RL experimentation.
statsmodels
Statistical modeling toolkit. OLS, GLM, logistic, ARIMA, time series, hypothesis tests, diagnostics, AIC/BIC, for rigorous statistical inference and econometric analysis.
sympy
Use this skill when working with symbolic mathematics in Python. This skill should be used for symbolic computation tasks including solving equations algebraically, performing calculus operations (derivatives, integrals, limits), manipulating algebraic expressions, working with matrices symbolically, physics calculations, number theory problems, geometry computations, and generating executable code from mathematical expressions. Apply this skill when the user needs exact symbolic results rather than numerical approximations, or when working with mathematical formulas that contain variables and parameters.
tooluniverse
Use this skill when working with scientific research tools and workflows across bioinformatics, cheminformatics, genomics, structural biology, proteomics, and drug discovery. This skill provides access to 600+ scientific tools including machine learning models, datasets, APIs, and analysis packages. Use when searching for scientific tools, executing computational biology workflows, composing multi-step research pipelines, accessing databases like OpenTargets/PubChem/UniProt/PDB/ChEMBL, performing tool discovery for research tasks, or integrating scientific computational resources into LLM workflows.
torch-geometric
Graph Neural Networks (PyG). Node/graph classification, link prediction, GCN, GAT, GraphSAGE, heterogeneous graphs, molecular property prediction, for geometric deep learning.
skills-consolidator
Merge and organize large Claude Code skill collections with conflict resolution. Use when combining skills from multiple sources, flattening directory structures, resolving duplicate names, preserving metadata, or preparing a curated skills library for distribution.
skills-duplicate-detector
Find duplicate, near-duplicate, and functionally overlapping Claude Code skills in a collection. Use when auditing a skills library for redundancy, after bulk-downloading from multiple sources, or before committing new skills to a repository.
stable-diffusion-helper
Generate and troubleshoot Stable Diffusion images: model installation and selection, prompt and negative-prompt engineering, CFG, sampler and step tuning, and VRAM optimization. Use when setting up SD models, improving photorealism, or diagnosing poor generation quality.
bulk-github-skills-downloader
Discover, clone, and consolidate Claude Code skills from many GitHub repositories at once. Use when bulk-downloading skills, building or refreshing a skills collection, flattening nested skill directories, or batch-importing from a curated list of repos.
claude-code_mrgoonie
Guidance on Claude Code, Anthropic's terminal-based agentic coding tool. Use when asked about Claude Code features, installation and authentication, slash commands, Agent Skills, MCP server configuration, hooks and plugins, IDE integration, enterprise deployment, or troubleshooting.
comfyui-workflow-helper
Build and tune ComfyUI workflows: node graphs, model loaders, samplers and schedulers, conditioning, and ControlNet. Use when creating or debugging a ComfyUI workflow, configuring nodes, installing checkpoints or LoRAs, or optimizing VRAM and generation speed.
google-adk-python_mrgoonie
Build AI agents with Google's Agent Development Kit (ADK) for Python. Use when creating tool-using or multi-agent systems, wiring sequential, parallel or loop workflow agents, integrating Google Search or code execution, evaluating agent performance, or deploying to Vertex AI Agent Engine or Cloud Run.
motion
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proxmox-auth
Authenticate to and manage a Proxmox VE cluster over SSH and the pvesh API. Use when querying cluster nodes, listing or controlling LXC containers and VMs, checking cluster and node status, or automating Proxmox administration.
keboola-data-engineering
Expert assistant for Keboola data platform. Builds working data pipelines, not just advice. Use for: data extraction, transformation, validation, orchestration, dashboard creation.
brand-guidelines
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.
learning-capture
Recognize and capture reusable patterns, workflows, and domain knowledge from work sessions into new skills. Use when completing tasks that involve novel approaches repeated 2+ times, synthesizing complex domain knowledge across conversations, discovering effective reasoning patterns, or developing workflow optimizations. Optimizes for high context window ROI by identifying patterns that will save 500+ tokens per reuse across 10+ future uses.
brand-analyzer
This skill should be used when the user requests brand analysis, brand guidelines creation, brand audits, or establishing brand identity and consistency standards. It provides comprehensive frameworks for analyzing brand elements and creating actionable brand guidelines based on requirements.
business-analytics-reporter
This skill should be used when analyzing business sales and revenue data from CSV files to identify weak areas, generate statistical insights, and provide strategic improvement recommendations. Use when the user requests a business performance report, asks to analyze sales data, wants to identify areas of weakness, or needs recommendations on business improvement strategies.
business-document-generator
This skill should be used when the user requests to create professional business documents (proposals, business plans, or budgets) from templates. It provides PDF templates and a Python script for generating filled documents from user data.
cicd-pipeline-generator
This skill should be used when creating or configuring CI/CD pipeline files for automated testing, building, and deployment. Use this for generating GitHub Actions workflows, GitLab CI configs, CircleCI configs, or other CI/CD platform configurations. Ideal for setting up automated pipelines for Node.js/Next.js applications, including linting, testing, building, and deploying to platforms like Vercel, Netlify, or AWS.
code-validation
Automated code validation for diff review, change hygiene, and red flag detection. Use when reviewing git diffs, PRs, or changed files for test disabling patterns, secrets, path portability issues, security flags, and large deletions. Supports Python, TypeScript, JavaScript, HTML, and CSS.
codebase-documenter
This skill should be used when writing documentation for codebases, including README files, architecture documentation, code comments, and API documentation. Use this skill when users request help documenting their code, creating getting-started guides, explaining project structure, or making codebases more accessible to new developers. The skill provides templates, best practices, and structured approaches for creating clear, beginner-friendly documentation.
docker-containerization
This skill should be used when containerizing applications with Docker, creating Dockerfiles, docker-compose configurations, or deploying containers to various platforms. Ideal for Next.js, React, Node.js applications requiring containerization for development, production, or CI/CD pipelines. Use this skill when users need Docker configurations, multi-stage builds, container orchestration, or deployment to Kubernetes, ECS, Cloud Run, etc.
merge-conflict-resolver
Analyze branch divergence, detect potential conflicts, and guide merge resolution for any Git repository. Auto-detects current branch or accepts parameters.
multi-agent-research
Apply Anthropic's production multi-agent research patterns for complex research tasks. Use when research involves multiple independent dimensions, requires synthesis across many sources, or needs parallelization for speed. Includes query complexity assessment, parallel execution, progressive search refinement, thinking strategies, and findings compression.
personal-assistant
This skill should be used whenever users request personal assistance tasks such as schedule management, task tracking, reminder setting, habit monitoring, productivity advice, time management, or any query requiring personalized responses based on user preferences and context. On first use, collects comprehensive user information including schedule, working habits, preferences, goals, and routines. Maintains an intelligent database that automatically organizes and prioritizes information, keeping relevant data and discarding outdated context.
pitch-deck
Generate professional PowerPoint pitch decks for startups and businesses. Use this skill when users request help creating investor pitch decks, sales presentations, or business pitch presentations. The skill follows standard 10-slide pitch deck structure and includes best practices for content and design.
pr-backlog-cleaner
Clean and normalize a large backlog of GitHub pull requests in messy repositories. This skill should be used when facing a repository with numerous stale, conflicted, or outdated PRs that need systematic review, conflict resolution, testing, and disposition (merge, close, or defer). Handles PR triage, automated rebasing, CI verification, risk assessment, and safe merging while maintaining default branch stability.
pr-comment-analysis
Extract, consolidate, and prioritize all comments from GitHub Pull Requests for systematic code review. Fetches both inline review comments and general PR conversation, then analyzes and organizes them by priority (critical bugs/security, design improvements, style nitpicks). Use when working with PR reviews, consolidating feedback from multiple reviewers, or creating action plans from review comments.
prd-creator
This skill should be used when creating, validating, or converting Product Requirements Documents (PRDs) to LLM-native format. Use this skill when the user asks to write a PRD, review a PRD for compliance, convert an existing PRD to machine-readable format, or ensure PRD quality for AI agent consumption. This skill is optimized for users working with agentic coding frameworks who need strict requirement specifications to prevent context poisoning, hallucination, and mesa-optimization.
prompt-optimization-analyzer
Active diagnostic tool for analyzing skill prompts to identify token waste, anti-patterns, trigger issues, and optimization opportunities. Use when reviewing skill prompts, debugging why skills aren't triggering, optimizing token usage, or preparing skills for publication. Provides specific, actionable suggestions with examples.
Security Validation
Pre-merge security validation detecting secrets, user-specific paths, insecure SSH configurations, and security-weakening flags
security-validation
Pre-merge security validation detecting secrets, user-specific paths, insecure SSH configurations, and security-weakening flags. Use before committing code/documentation, before creating PRs, or during QA validation. Supports automated scanning with severity-based enforcement (CRITICAL blocks merge, HIGH requires fixes).
seo-optimizer
This skill should be used when analyzing HTML/CSS websites for SEO optimization, fixing SEO issues, generating SEO reports, or implementing SEO best practices. Use when the user requests SEO audits, optimization, meta tag improvements, schema markup implementation, sitemap generation, or general search engine optimization tasks.
skill-debugging-assistant
Debug, diagnose, and troubleshoot skill issues including trigger failures, parameter problems, prompt conflicts, and SKILL.md structural issues. Use when skills don't activate as expected, trigger incorrectly, produce unexpected behavior, conflict with system instructions, or fail packaging validation. Analyzes YAML frontmatter, descriptions, progressive disclosure, token budget, absolute statements, and reference file organization. For skill creators reviewing, validating, or fixing skill problems.
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