depmap
Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.
bids
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bgpt-paper-search
Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.
consciousness-council
Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me think through this from all sides", "council mode", "mind council", or "deliberate on this". Also trigger when the user faces a dilemma, trade-off, or complex choice with no obvious answer.
bulk-rnaseq
End-to-end bulk RNA-seq orchestrator — takes raw FASTQ reads through QC and trimming (FastQC, fastp/Trim Galore), alignment and quantification (STAR, Salmon, featureCounts), assembles a gene-level counts matrix, then hands off to differential expression (pydeseq2), pathway/GSEA enrichment (pathway-enrichment), and publication figures (scientific-visualization). Use whenever the user has bulk RNA-seq reads or quant output and wants a complete, reproducible differential-expression workflow — e.g. "analyze my RNA-seq", "FASTQ to DESeq2", "run nf-core/rnaseq", "STAR/Salmon quantification", "build a counts matrix for DESeq2", or "go from reads to differentially expressed genes and enriched pathways". Routes between an nf-core/rnaseq (Nextflow) path and a standalone STAR/Salmon path, and covers experimental design, strandedness, and QC gates. For single-cell RNA-seq use the scanpy skill instead.
arbor
Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE-bench / Kaggle-style optimization", or any long-horizon "make this artifact better and don't just memorize the dev set" task. Trigger it even when the user doesn't say "Arbor" or "hypothesis tree" but describes repeated experiment-and-evaluate loops, branching exploration of competing ideas, or worries about a dev/test gap. Runs Claude itself as the coordinator with subagent executors in isolated git worktrees; for the standalone `arbor` CLI tool see references/arbor-upstream.md.
autoskill
Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing scientific-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on what they actually do. Requires the screenpipe daemon (https://github.com/screenpipe/screenpipe) running locally on port 3030 — the skill has no other data source and will refuse to run if screenpipe is unreachable. All detection runs locally; only redacted cluster summaries reach the LLM.
youtube-downloader
Download YouTube videos with customizable quality and format options. Use this skill when the user asks to download, save, or grab YouTube videos. Supports various quality settings (best, 1080p, 720p, 480p, 360p), multiple formats (mp4, webm, mkv), and audio-only downloads as MP3.
webapp-testing
Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.
tailored-resume-generator
Analyzes job descriptions and generates tailored resumes that highlight relevant experience, skills, and achievements to maximize interview chances
developer-growth-analysis
Analyzes your recent Claude Code chat history to identify coding patterns, development gaps, and areas for improvement, curates relevant learning resources from HackerNews, and automatically sends a personalized growth report to your Slack DMs.
content-research-writer
Assists in writing high-quality content by conducting research, adding citations, improving hooks, iterating on outlines, and providing real-time feedback on each section. Transforms your writing process from solo effort to collaborative partnership.
connect
Connect Claude to any app. Send emails, create issues, post messages, update databases - take real actions across Gmail, Slack, GitHub, Notion, and 1000+ services.
connect-apps
Connect Claude to external apps like Gmail, Slack, GitHub. Use this skill when the user wants to send emails, create issues, post messages, or take actions in external services.
competitive-ads-extractor
Extracts and analyzes competitors' ads from ad libraries (Facebook, LinkedIn, etc.) to understand what messaging, problems, and creative approaches are working. Helps inspire and improve your own ad campaigns.
changelog-generator
Automatically creates user-facing changelogs from git commits by analyzing commit history, categorizing changes, and transforming technical commits into clear, customer-friendly release notes. Turns hours of manual changelog writing into minutes of automated generation.
canvas-design
Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.
brand-guidelines
Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.
artifacts-builder
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.
file-organizer
Intelligently organizes your files and folders across your computer by understanding context, finding duplicates, suggesting better structures, and automating cleanup tasks. Reduces cognitive load and keeps your digital workspace tidy without manual effort.
slack-gif-creator
Toolkit for creating animated GIFs optimized for Slack, with validators for size constraints and composable animation primitives. This skill applies when users request animated GIFs or emoji animations for Slack from descriptions like "make me a GIF for Slack of X doing Y".
domain-name-brainstormer
Generates creative domain name ideas for your project and checks availability across multiple TLDs (.com, .io, .dev, .ai, etc.). Saves hours of brainstorming and manual checking.
raffle-winner-picker
Picks random winners from lists, spreadsheets, or Google Sheets for giveaways, raffles, and contests. Ensures fair, unbiased selection with transparency.
meeting-insights-analyzer
Analyzes meeting transcripts and recordings to uncover behavioral patterns, communication insights, and actionable feedback. Identifies when you avoid conflict, use filler words, dominate conversations, or miss opportunities to listen. Perfect for professionals seeking to improve their communication and leadership skills.
mcp-builder
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).
lead-research-assistant
Identifies high-quality leads for your product or service by analyzing your business, searching for target companies, and providing actionable contact strategies. Perfect for sales, business development, and marketing professionals.
langsmith-fetch
Debug LangChain and LangGraph agents by fetching execution traces from LangSmith Studio. Use when debugging agent behavior, investigating errors, analyzing tool calls, checking memory operations, or examining agent performance. Automatically fetches recent traces and analyzes execution patterns. Requires langsmith-fetch CLI installed.
invoice-organizer
Automatically organizes invoices and receipts for tax preparation by reading messy files, extracting key information, renaming them consistently, and sorting them into logical folders. Turns hours of manual bookkeeping into minutes of automated organization.
internal-comms
A set of resources to help me write all kinds of internal communications, using the formats that my company likes to use. Claude should use this skill whenever asked to write some sort of internal communications (status reports, leadership updates, 3P updates, company newsletters, FAQs, incident reports, project updates, etc.).
image-enhancer
Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity. Perfect for preparing images for presentations, documentation, or social media posts.
skill-creator
Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.
twitter-algorithm-optimizer
Analyze and optimize tweets for maximum reach using Twitter's open-source algorithm insights. Rewrite and edit user tweets to improve engagement and visibility based on how the recommendation system ranks content.
theme-factory
Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc. There are 10 pre-set themes with colors/fonts that you can apply to any artifact that has been creating, or can generate a new theme on-the-fly.
template-skill
Replace with description of the skill and when Claude should use it.
skill-share
A skill that creates new Claude skills and automatically shares them on Slack using Rube for seamless team collaboration and skill discovery.
using-skillshub
How to install, link, and manage AI-agent skills with the `skillshub` CLI. Use this skill whenever the user wants to install a skill, add or remove a tap, share skills across multiple coding agents, sync `~/.skillshub/`, troubleshoot a missing or broken skill, write a `SKILL.md`, or do anything that touches the `skillshub` command — even when they describe the goal without naming the tool (e.g. "I want this skill in Cursor too", "why doesn't Codex see my skill", "package this folder as a skill").
zyfai
Earn yield on any Ethereum wallet on Base, Arbitrum, and Plasma. Use when a user wants passive DeFi yield on their funds. Deploys a non-custodial deterministic subaccount (Safe) linked to their EOA, enables automated yield optimization, and lets them deposit/withdraw anytime.
zerion
Interpreted crypto wallet data for AI agents. Use when an agent needs portfolio values, token positions, DeFi positions, NFT holdings, transaction history, PnL data, token prices, charts, gas prices, swap quotes, or DApp information across 41+ chains. Zerion transforms raw blockchain data into agent-ready JSON with USD values, protocol labels, and enriched metadata. Supports x402 pay-per-request ($0.01 USDC on Base) and API key access. Triggers on mentions of portfolio, wallet analysis, positions, transactions, PnL, profit/loss, DeFi, token balances, NFTs, swap quotes, gas prices, or Zerion.
zapper
Placeholder for Zapper skill.
signals
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signa
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quicknode
Blockchain RPC and data access via Quicknode. Use when an agent needs to read onchain data (balances, token prices, transaction status, gas estimates, block data) across Base, Ethereum, Polygon, Solana, or Unichain. Supports both API key access and x402 wallet-based pay-per-request access with no account needed. Triggers on mentions of RPC, blockchain data, onchain queries, token balances, gas estimation, block number, transaction receipt, Quicknode, or x402.
qrcoin
Interact with QR Coin auctions on Base. Use when the user wants to participate in qrcoin.fun QR code auctions — check auction status, view current bids, create new bids, or contribute to existing bids. QR Coin lets you bid to display URLs on QR codes; the highest bidder's URL gets encoded.
productclank-campaigns
Community-powered growth for builders. Boost amplifies your social posts with authentic community engagement (replies, likes, reposts). Discover finds relevant conversations and generates AI-powered replies at scale. Use Boost when the user has a post URL. Use Discover when the user wants to find and engage in conversations about their product.
Uniswap Trading
Integrate Uniswap swaps into frontends, backends, and smart contracts — V2/V3/V4 support via Trading API, Universal Router, or direct contract calls.
pmfi-parbitrage
Deposit Base USDC into PMFI pARBITRAGE and withdraw pARB back to USDC through Bankr.
orlix
Personal AI Operating System on Base. Use when an agent wants to analyze any Base token (live price, risk verdict, liquidity), chat with 19 frontier AI models (Claude, GPT-4o, Grok, Gemini, DeepSeek), deploy or manage B20 tokens (Base Beryl native precompile — config validation, ABI-encoded deployment tx, live gas + nonce from Base RPC), check ETH or ERC-20 balances, get current gas prices, read any ERC-20 on Base, or verify a tx receipt. No auth required.
opensea
Query NFT and token data, trade NFTs on Seaport, swap ERC20 tokens via DEX aggregator, configure wallet signing providers, and build/register/gate AI agent tools on Base. Covers the full OpenSea developer surface across CLI, MCP server, shell scripts, and SDK. Pick the right sub-skill using the routing table below, then read that sub-skill's SKILL.md for operational detail.
onchainkit
Build onchain applications with React components and TypeScript utilities from Coinbase's OnchainKit. Use when users want to create crypto wallets, swap tokens, mint NFTs, build payments, display blockchain identities, or develop any onchain app functionality. Supports wallet connection, transaction building, token operations, identity management, and complete onchain app development workflows.
nookplot
Decentralized coordination network for AI agents on Base (Ethereum L2). Use when an agent needs to register an on-chain identity, publish content, message other agents, hire a specialist via the marketplace, post or claim bounties, build reputation, collaborate on shared projects, mine NOOK by solving research challenges, deploy a standalone on-chain agent with curated knowledge, or earn revenue through agreements and rewards. Triggers on mentions of agent network, agent coordination, decentralized agents, NOOK token, mining challenges, knowledge bundles, agent reputation, agent marketplace, ERC-2771 meta-transactions, prepare-sign-relay, AgentFactory, or Nookplot.
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