plotly
Interactive visualization library. Use when you need hover info, zoom, pan, or web-embeddable charts. Best for dashboards, exploratory analysis, and presentations. For static publication figures use matplotlib or scientific-visualization.
arboreto
Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
anndata
Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.
alphafold-database
Access AlphaFold 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
aeon
This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
adaptyv
Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
webapp-testing
Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.
web-artifacts-builder
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.
theme-factory
Toolkit for styling artifacts with a theme. These artifacts can be slides, docs, reportings, HTML landing pages, etc. There are 10 pre-set themes with colors/fonts that you can apply to any artifact that has been creating, or can generate a new theme on-the-fly.
slack-gif-creator
Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts. Use when users request animated GIFs for Slack like "make me a GIF of X doing Y for Slack."
skill-creator
Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.
mcp-builder
Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).
internal-comms
A set of resources to help me write all kinds of internal communications, using the formats that my company likes to use. Claude should use this skill whenever asked to write some sort of internal communications (status reports, leadership updates, 3P updates, company newsletters, FAQs, incident reports, project updates, etc.).
frontend-design
Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.
doc-coauthoring
Guide users through a structured workflow for co-authoring documentation. Use when user wants to write documentation, proposals, technical specs, decision docs, or similar structured content. This workflow helps users efficiently transfer context, refine content through iteration, and verify the doc works for readers. Trigger when user mentions writing docs, creating proposals, drafting specs, or similar documentation tasks.
polars
Fast in-memory DataFrame library for datasets that fit in RAM. Use when pandas is too slow but data still fits in memory. Lazy evaluation, parallel execution, Apache Arrow backend. Best for 1-100GB datasets, ETL pipelines, faster pandas replacement. For larger-than-RAM data use dask or vaex.
pptx-posters
Create research posters using HTML/CSS that can be exported to PDF or PPTX. Use this skill ONLY when the user explicitly requests PowerPoint/PPTX poster format. For standard research posters, use latex-posters instead. This skill provides modern web-based poster design with responsive layouts and easy visual integration.
protocolsio-integration
Integration with protocols.io API for managing scientific protocols. This skill should be used when working with protocols.io to search, create, update, or publish protocols; manage protocol steps and materials; handle discussions and comments; organize workspaces; upload and manage files; or integrate protocols.io functionality into workflows. Applicable for protocol discovery, collaborative protocol development, experiment tracking, lab protocol management, and scientific documentation.
pubchem-database
Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics.
pubmed-database
Direct REST API access to PubMed. Advanced Boolean/MeSH queries, E-utilities API, batch processing, citation management. For Python workflows, prefer biopython (Bio.Entrez). Use this for direct HTTP/REST work or custom API implementations.
pufferlib
High-performance reinforcement learning framework optimized for speed and scale. Use when you need fast parallel training, vectorized environments, multi-agent systems, or integration with game environments (Atari, Procgen, NetHack). Achieves 2-10x speedups over standard implementations. For quick prototyping or standard algorithm implementations with extensive documentation, use stable-baselines3 instead.
astropy
Comprehensive Python library for astronomy and astrophysics. This skill should be used when working with astronomical data including celestial coordinates, physical units, FITS files, cosmological calculations, time systems, tables, world coordinate systems (WCS), and astronomical data analysis. Use when tasks involve coordinate transformations, unit conversions, FITS file manipulation, cosmological distance calculations, time scale conversions, or astronomical data processing.
pydeseq2
Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.
pydicom
Python library for working with DICOM (Digital Imaging and Communications in Medicine) files. Use this skill when reading, writing, or modifying medical imaging data in DICOM format, extracting pixel data from medical images (CT, MRI, X-ray, ultrasound), anonymizing DICOM files, working with DICOM metadata and tags, converting DICOM images to other formats, handling compressed DICOM data, or processing medical imaging datasets. Applies to tasks involving medical image analysis, PACS systems, radiology workflows, and healthcare imaging applications.
backend-architect
Expert senior en architecture backend pour accompagner le développement (conception, implémentation, review, refactoring). Architecture hexagonale, DDD, SOLID, clean code, tests. Utiliser pour concevoir de nouvelles features, développer du code, reviewer, refactorer, ou résoudre des problèmes architecturaux.
security-guardian
Expert en sécurité applicative pour détecter les vulnérabilités, auditer le code, et guider les bonnes pratiques de sécurité. OWASP Top 10, authentification, autorisation, cryptographie, gestion de secrets. Utiliser pour audits sécurité, reviews de code sensible, conception de features sécurisées, ou résolution de failles.
convex
Convex backend development patterns, validators, indexes, actions, queries, mutations, file storage, scheduling, React hooks, and components. Use when writing Convex code, debugging Convex issues, or planning Convex architecture.
sheets-cli
Read, write, and update Google Sheets data via CLI. Use when the user asks to read spreadsheet data, update cells, append rows, or work with Google Sheets. Triggers on mentions of spreadsheets, sheets, Google Sheets, tabular data in the cloud, or specific sheet names like "Projects" or "Tasks".
oracle
Use the @steipete/oracle CLI to bundle a prompt plus the right files and get a second-model review (API or browser) for debugging, refactors, design checks, or cross-validation.
github-repo-skill
Guide for creating new GitHub repos and best practice for existing GitHub repos, applicable to both code and non-code projects
thx-boris
Meta-workflow for using Claude Code effectively, based on patterns from Boris Cherny (Claude Code creator). Use when setting up a new project with Claude Code, optimizing an existing workflow, creating CLAUDE.md files, designing subagents, configuring hooks, or running parallel Claude sessions. Triggers on "how should I structure my CLAUDE.md", "create a subagent for X", "set up hooks", "optimize my Claude Code setup".
agent-workflow
Expert system for designing and architecting AI agent workflows based on proven Meta methodologies. Use when users need to build AI agents, create agent workflows, solve problems using agentic systems, integrate multiple tools into agent architectures, or need guidance on agent design patterns. Helps translate business problems into structured agent solutions with clear scope, tool integration, and multi-layer architecture planning.
prd-writer
Full 5-stage PRD framework for complex features. Use for deep PRD work via /spec --deep full-prd. For quick feature specs, use /spec --feature instead.
context-engineering
[ARCHIVED] Full 4D Context Canvas reference. For new AI features, use /spec --ai. For debugging, use /ai-debug. For quality checks, use /context-check.
prompt-engineering
Expert prompt optimization system for building production-ready AI features. Use when users request help improving prompts, want to create system prompts, need prompt review/critique, ask for prompt optimization strategies, want to analyze prompt effectiveness, mention prompt engineering best practices, request prompt templates, or need guidance on structuring AI instructions. Also use when users provide prompts and want suggestions for improvement.
pmf-survey
Create and analyze a PMF survey using Rahul Vohra's Superhuman framework. The magic 40% benchmark for product-market fit.
issue-audit
Understand how a team organizes work in Linear. Helps PMs onboarding to new teams learn conventions, see examples, and know what questions to ask.
reflect
Pattern recognition across your product decisions. Analyzes saved strategy sessions to surface themes, recurring risks, and suggested next steps.
shape-up
Shape work using the Shape Up methodology (Ryan Singer, Basecamp). Walk through the 4-step shaping process to create pitches ready for betting. Distinguishes between established product mode (fixed time, variable scope) and new product mode (looser constraints). Use when planning cycle work, writing pitches, or coaching PMs on shaping.
ai-health-check
Pre-launch health check that blocks you from shipping broken AI features. Grades 6 dimensions (model selection, data quality, cost, monitoring, failure UX, optimization).
ai-debug
Diagnose why an AI feature is underperforming, hallucinating, or behaving inconsistently. Uses 4D audit to work backwards from symptoms to root cause.
ai-cost-check
Calculate AI feature costs and challenge if you actually need it. Invokes ai-cost-analyzer agent for detailed economics modeling.
pm-frameworks
Expert knowledge of proven product management frameworks for discovery, growth, measurement, planning, and AI-era practices.
project-health
Deep-dive health check on a single Linear project. Produces assessment with 7 dimensions - On Track / At Risk / Stalled.
agency-ladder
Plan the v1→v2→v3 agency progression for AI features. Walk through mapping how autonomy increases over time, define promotion criteria, and generate artifacts for stakeholder alignment. Based on CC/CD framework.
spec
Write specifications at the right depth for any project. Progressive disclosure from quick Linear issues to full AI feature specs. Embeds Linear Method philosophy (brevity, clarity, momentum) with context engineering for AI features. Use for any spec work - quick tasks, features, or AI products.
start-evals
Start AI evals without overengineering. Create your first 20 test cases in a spreadsheet using PM-Friendly Evals approach.
lno-prioritize
Find out if you're spending time on the wrong things. Categorize backlog by Leverage/Neutral/Overhead and challenge your time allocation.
now-next-later
Generate a Now-Next-Later roadmap using Janna Bastow's framework. Communicates sequence and certainty without false dates.
growth-loops
Find your growth loop or stay stuck in linear acquisition hell. Identify viral, content, network, and paid loop opportunities using Elena Verna's framework.
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